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David W. Sanders
Researcher at Princeton University
Publications - 26
Citations - 3773
David W. Sanders is an academic researcher from Princeton University. The author has contributed to research in topics: Medicine & Intracellular. The author has an hindex of 11, co-authored 19 publications receiving 2463 citations. Previous affiliations of David W. Sanders include University of Texas Southwestern Medical Center & University of Texas at Dallas.
Papers
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Journal ArticleDOI
Distinct tau prion strains propagate in cells and mice and define different tauopathies.
David W. Sanders,Sarah K. Kaufman,Sarah L. DeVos,Apurwa M Sharma,Hilda Mirbaha,Aimin Li,Scarlett J. Barker,Alex C. Foley,Julian R. Thorpe,Louise C. Serpell,Timothy M. Miller,Lea T. Grinberg,William W. Seeley,Marc I. Diamond +13 more
TL;DR: Tau demonstrates essential characteristics of a prion, which might explain the phenotypic diversity of tauopathies and could enable more effective diagnosis and therapy.
Journal ArticleDOI
Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome.
Yongdae Shin,Yongdae Shin,Yi-Che Chang,Daniel S.W. Lee,Joel Berry,David W. Sanders,Pierre Ronceray,Ned S. Wingreen,Mikko Haataja,Clifford P. Brangwynne,Clifford P. Brangwynne +10 more
TL;DR: CasDrop is used, a novel CRISPR-Cas9-based optogenetic technology, to show that various IDPs phase separate into liquid condensates that mechanically exclude chromatin as they grow and preferentially form in low-density, largely euchromatic regions.
Journal ArticleDOI
Neuronal activity enhances tau propagation and tau pathology in vivo
Jessica W. Wu,S. Abid Hussaini,Isle M Bastille,Gustavo A. Rodriguez,Ana Mrejeru,Kelly Rilett,David W. Sanders,Casey Cook,Hongjun Fu,Rick A C M Boonen,Mathieu Herman,Eden Nahmani,Sheina Emrani,Y Helen Figueroa,Marc I. Diamond,Catherine L. Clelland,Selina Wray,Karen Duff +17 more
TL;DR: It is shown that physiological tau released from donor cells can transfer to recipient cells via the medium, suggesting that at least one mechanism by which tau can transfer is via the extracellular space.
Journal ArticleDOI
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization
David W. Sanders,Nancy Kedersha,Daniel S.W. Lee,Amy R. Strom,Victoria Drake,Joshua A. Riback,Dan Bracha,Jorine M. Eeftens,Allana Iwanicki,Alicia Wang,Ming-Tzo Wei,Gena Whitney,Shawn M. Lyons,Paul A. Anderson,William M. Jacobs,Pavel Ivanov,Clifford P. Brangwynne,Clifford P. Brangwynne +17 more
TL;DR: Inspired by patchy colloid theory, this work proposes a general framework by which competing networks give rise to compositionally specific and tunable condensates, while relative linkage between nodes underlies multiphase organization.
Journal ArticleDOI
Composition-dependent thermodynamics of intracellular phase separation
Joshua A. Riback,Lian Zhu,Mylene C. Ferrolino,Michele Tolbert,Diana M. Mitrea,David W. Sanders,Ming-Tzo Wei,Richard W. Kriwacki,Clifford P. Brangwynne +8 more
TL;DR: It is found that heterotypic interactions among protein and RNA components stabilize various archetypal intracellular condensates—including the nucleolus, Cajal bodies, stress granules and P-bodies—implying that the composition of condensate is finely tuned by the thermodynamics of the underlying biomolecular interaction network.