Abelardo Aguilera

TL;DR: The results suggest that mesothelial cells have an active role in the structural and functional alteration of the peritoneum during peritoneal dialysis, and suggest potential targets for the design of new dialysis solutions and markers for the monitoring of patients.

TL;DR: Recent advances on understanding the mechanisms that are implicated in peritoneal structural alterations have allowed the identification of the EMT of MC as a potential therapeutic target of membrane failure, and this article provides a comprehensive review of recent advances.

TL;DR: It is suggested that mesothelial cells that have undergone epithelial-to-mesenchymal transition are the main source of VEGF in PD patients and therefore may be responsible for a high peritoneal transport rate.

TL;DR: Abdominal hernias and peritoneal leaks are very frequent in the PD population and advanced age, polycystic kidney disease, and high body mass index are independent risk factors for their development.

TL;DR: It is demonstrated that TGF-β1 drives the peritoneal deterioration induced by dialysis fluid and highlights a role of TGF -β1-mediated MMT in the pathophysiology of peritoneale-membrane dysfunction.