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Abu Tholib Aman
Researcher at Gadjah Mada University
Publications - 42
Citations - 816
Abu Tholib Aman is an academic researcher from Gadjah Mada University. The author has contributed to research in topics: Medicine & Rotavirus. The author has an hindex of 10, co-authored 33 publications receiving 634 citations. Previous affiliations of Abu Tholib Aman include University of Bristol.
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Journal ArticleDOI
Effect of cinnamon oil on icaA expression and biofilm formation by Staphylococcus epidermidis.
Titik Nuryastuti,Titik Nuryastuti,Henny C. van der Mei,Henk J. Busscher,Susi Iravati,Abu Tholib Aman,Bastiaan P. Krom +6 more
TL;DR: Cinnamon oil showed antimicrobial activity against both planktonic and biofilm cultures of clinical S. epidermidis strains, and CLSM images indicated that cinnamon oil is able to detach and kill existing biofilms.
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A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.
Abu Tholib Aman,S. Fraser,Ethan A. Merritt,C. Rodigherio,M. J. Kenny,Misol Ahn,Wim G. J. Hol,Neil A. Williams,Wayne I. Lencer,Timothy R. Hirst +9 more
TL;DR: It is demonstrated that GM1 binding, contrary to expectation, is not sufficient to initiate toxin action, and the engineering and crystallographic structure of a mutant cholera toxin is reported, with a His to Ala substitution in the B subunit at position 57.
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Biofilm formation and antibiotic resistance of Klebsiella pneumoniae isolated from clinical samples in a tertiary care hospital, Klaten, Indonesia
Hera Nirwati,Kian Sinanjung,Fahrina Fahrunissa,Fernando Wijaya,Sarastia Napitupulu,Vania P. Hati,Mohamad S. Hakim,Andreanita Meliala,Abu Tholib Aman,Titik Nuryastuti +9 more
TL;DR: Most of the K. pneumoniae isolates demonstrated resistance to a wide range of antibiotics and are biofilm producers.
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Protective Mucosal Immunity to Ocular Herpes Simplex Virus Type 1 Infection in Mice by Using Escherichia coli Heat-Labile Enterotoxin B Subunit as an Adjuvant
TL;DR: The protective efficacy of the immune response induced using rEtxB as an adjuvant was assessed following ocular challenge of immunized and mock-immunized mice, and a significant reduction in the incidence of lid disease and zosteriform spread was observed in immunized animals.
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Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity.
TL;DR: In this article, the authors examined the structural basis for the difference in toxicity between cholera toxin and E. coli heat-labile enterotoxin (Etx) by engineering a set of mutant and hybrid toxins and testing their activity in human epithelial (T84) cells.