M
Mohamad S. Hakim
Researcher at Gadjah Mada University
Publications - 52
Citations - 708
Mohamad S. Hakim is an academic researcher from Gadjah Mada University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 37 publications receiving 420 citations. Previous affiliations of Mohamad S. Hakim include Erasmus University Rotterdam & Erasmus University Medical Center.
Papers
More filters
Journal ArticleDOI
Biofilm formation and antibiotic resistance of Klebsiella pneumoniae isolated from clinical samples in a tertiary care hospital, Klaten, Indonesia
Hera Nirwati,Kian Sinanjung,Fahrina Fahrunissa,Fernando Wijaya,Sarastia Napitupulu,Vania P. Hati,Mohamad S. Hakim,Andreanita Meliala,Abu Tholib Aman,Titik Nuryastuti +9 more
TL;DR: Most of the K. pneumoniae isolates demonstrated resistance to a wide range of antibiotics and are biofilm producers.
Journal ArticleDOI
The global burden of hepatitis E outbreaks: a systematic review.
Mohamad S. Hakim,Mohamad S. Hakim,Wenshi Wang,Wichor M. Bramer,Jiawei Geng,Fen Huang,Robert A. de Man,Maikel P. Peppelenbosch,Qiuwei Pan +8 more
TL;DR: It is highlighted that HEV outbreak is not new, yet it is a continuous global health problem, and the control measures mainly depend upon improvement of sanitation and hygiene.
Journal ArticleDOI
Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV.
Wenshi Wang,Lei Xu,Johannes H. Brandsma,Yijin Wang,Mohamad S. Hakim,Mohamad S. Hakim,Xinying Zhou,Yuebang Yin,Gwenny M. Fuhler,Luc J. W. van der Laan,C. Janneke van der Woude,Dave Sprengers,Herold J. Metselaar,Ron Smits,Raymond A. Poot,Maikel P. Peppelenbosch,Qiuwei Pan +16 more
TL;DR: A novel mechanism of convergent transcription of ISGs by TNF-α and IFN-α is revealed, which augments their antiviral activity against HCV and HEV.
Journal ArticleDOI
IRF-1, RIG-I and MDA5 display potent antiviral activities against norovirus coordinately induced by different types of interferons.
Wen Dang,Lei Xu,Yuebang Yin,Sunrui Chen,Wenshi Wang,Mohamad S. Hakim,Kyeong-Ok Chang,Maikel P. Peppelenbosch,Qiuwei Pan +8 more
TL;DR: It is found that HuNoV RNA replication was sensitive to all types of IFNs, including IFN&agr; (type I),IFN&ggr;(type II), IFN &lgr;1 and 3 (type III), and worked cooperatively with type I or type III IFNs to induce ISGs and subsequently inhibit Hu noV replication.
Journal ArticleDOI
The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response.
Wenshi Wang,Yijin Wang,Changbo Qu,Shan Wang,Jian-hua Zhou,Wanlu Cao,Lei Xu,Buyun Ma,Mohamad S. Hakim,Yuebang Yin,Tian-Cheng Li,Maikel P. Peppelenbosch,Jingmin Zhao,Qiuwei Pan +13 more
TL;DR: HEV infection elicits an active IFN‐related antiviral response in vitro and in patients, triggered by the viral RNA and mediated by IFN regulatory factors 3 and 7 and the Janus kinase–signal transducer and activator of transcription cascade; these findings have revealed new insights into HEV–host interactions and provided the basis for understanding the pathogenesis and outcome of HEV infection.