A
Abul K. Abbas
Researcher at University of California, San Francisco
Publications - 252
Citations - 36528
Abul K. Abbas is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 88, co-authored 251 publications receiving 34965 citations. Previous affiliations of Abul K. Abbas include American Association for the Advancement of Science & Brigham and Women's Hospital.
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Journal ArticleDOI
Immortalization of murine connective tissue-type mast cells at multiple stages of their differentiation by coculture of splenocytes with fibroblasts that produce Kirsten sarcoma virus.
D S Reynolds,W E Serafin,Douglas V. Faller,D. A. Wall,Abul K. Abbas,Ann M. Dvorak,K F Austen,Richard L. Stevens +7 more
TL;DR: 15 novel mast cell lines that were derived by coculturing murine splenocytes with fibroblasts that produce a Ki-ras-containing murine sarcoma virus are described to illustrate that murine mast cells can express a continuum of phenotypes.
Journal Article
Interrelationships of surface immunoglobulin and Fc receptors on mouse B lymphocytes.
Abul K. Abbas,Emil R. Unanue +1 more
TL;DR: Results suggest that ligand binding to surface Ig induces some alteration which allows the Ig to enter into an association with Fc receptors, indicating that these two molecules are independent moieties.
Journal ArticleDOI
Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex.
TL;DR: Results identify the transmembrane residues of mu heavy chain that control binding to calnexin and Ig alpha, and suggest thatCalnexin-dependent intracellular retention is an important control mechanism for expression of the BCR complex.
Journal ArticleDOI
Cytoplasmic tail deletion converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions.
TL;DR: The molecular mass of the cytoplasmic tail-deleted phosphatidylinositol-linked Ig molecule is consistent with cleavage of the transmembrane residues during processing, and may regulate the mode of expression of membrane proteins and thereby influence their functional capabilities.
Journal Article
Anergy in immature B lymphocytes. Differential responses to receptor-mediated stimulation and T helper cells.
TL;DR: In neonatal B lymphocytes, cross-linking of membrane Ig in the absence of Th cells has a net inhibitory effect, and this inhibition is overcome by T cell help, suggesting that unresponsiveness or tolerance to thymus-independent Ag is induced in the B cells themselves, but tolerance to Th cell compartment resides primarily in the T cell compartment.