A
Ada Rephaeli
Researcher at Tel Aviv University
Publications - 111
Citations - 3236
Ada Rephaeli is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Prodrug & Butyrate. The author has an hindex of 34, co-authored 110 publications receiving 3103 citations. Previous affiliations of Ada Rephaeli include Weizmann Institute of Science & Rabin Medical Center.
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Doxorubicin-DNA Adducts Induce a Non-Topoisomerase II–Mediated Form of Cell Death
TL;DR: It is shown that doxorubicin-DNA adducts induce a more cytotoxic response in HL-60 cells than doxorbicin as a single agent, and that theseAdducts are more cytOToxic than topoisomerase II-mediated lesions.
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The power and potential of doxorubicin-DNA adducts.
TL;DR: The adducts appear to be more cytotoxic than doxorubicin alone, and also less susceptible to drug‐efflux forms of resistance, they offer new approaches to improving the anticancer activity of the anthracyclines.
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Novel anticancer prodrugs of butyric acid. 2.
Abraham Nudelman,Margaretta Ruse,Adina Aviram,Ester Rabizadeh,Matityahu Shaklai,Yael Zimrah,Ada Rephaeli +6 more
TL;DR: In vivo and in vitro results suggest that (pivaloyloxy)methyl butyrate (1a) is a potential antineoplastic agent.
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The effect of membrane potential on the mammalian sodium‐potassium pump reconstituted into phospholipid vesicles.
TL;DR: Measurement of fluorescence changes of the carbocyanine dye DiS‐C3‐(5) showed that the ionophores generated potentials of the expected orientation and of sufficient stability for their effects on active transport to be assessed, demonstrating that values of diffusion potentials calculated from the Nernst or constant‐field equation are accurate.
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Derivatives of butyric acid as potential anti-neoplastic agents.
TL;DR: The results suggest that AN‐9 is a potential anti‐neoplastic agent ar well as a tool for investigation of the differentiation induction mechanism.