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Adam J. Broomer
Researcher at Life Technologies
Publications - 1
Citations - 137
Adam J. Broomer is an academic researcher from Life Technologies. The author has contributed to research in topics: Transcriptome & Gene expression profiling. The author has an hindex of 1, co-authored 1 publications receiving 134 citations.
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Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations.
Brian B. Tuch,Rebecca R. Laborde,Xing Xu,Jian Gu,Christina A. Bormann Chung,Cinna Monighetti,Sarah Stanley,Kerry D. Olsen,Jan L. Kasperbauer,Eric J. Moore,Adam J. Broomer,Ruoying Tan,Pius Brzoska,Matthew W. Muller,Asim Siddiqui,Yan W. Asmann,Yongming Sun,Scott Kuersten,Melissa Barker,Francisco M. De La Vega,David I. Smith +20 more
TL;DR: It is found that allelic imbalance in the tumor is associated with Copy number mutations and that copy number mutations are, in turn, strongly associated with changes in transcript abundance, which support a model in which allele-specific deletions and duplications drive allele- specific changes in gene expression in the developing tumor.