Christina A. Bormann Chung

TL;DR: It is found that allelic imbalance in the tumor is associated with Copy number mutations and that copy number mutations are, in turn, strongly associated with changes in transcript abundance, which support a model in which allele-specific deletions and duplications drive allele- specific changes in gene expression in the developing tumor.

TL;DR: A systematic analysis of 50 human genomes from 11 diverse global populations sequenced at high coverage identifies subtle variations across populations in the proportion of neutral versus deleterious variation and finds that genome-wide statistics vary in admixed populations even once ancestry proportions have been factored in.

TL;DR: A whole methylome sequencing study that compares two different bisulfite conversion methods (in solution versus in gel), utilizing the high throughput of the SOLiD™ System is presented.

TL;DR: Next-generation, massively parallel sequencing (MPS) technology (specifically the Applied Biosystems sequencing by oligonucleotide ligation and detection (SOLiD™) system) is a powerful investigative tool for rapid, cost-effective and parallel microbial whole-genome characterization of monomorphic pathogens.

TL;DR: Evidence is uncovered that additional DNA binding enzymes may contribute to fluoroquinolone resistance and further implicate environmental bacteria as a reservoir for antibiotic resistance.