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Brian B. Tuch
Researcher at University of California, San Francisco
Publications - 48
Citations - 11286
Brian B. Tuch is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Trk receptor & Gene. The author has an hindex of 29, co-authored 47 publications receiving 9020 citations. Previous affiliations of Brian B. Tuch include Genentech & Life Technologies.
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Journal ArticleDOI
mRNA-Seq whole-transcriptome analysis of a single cell.
Fuchou Tang,Catalin Barbacioru,Yangzhou Wang,Ellen Nordman,Clarence Lee,Nanlan Xu,Xiaohui Wang,John Bodeau,Brian B. Tuch,Asim Siddiqui,Kaiqin Lao,M. Azim Surani +11 more
TL;DR: A single-cell digital gene expression profiling assay with only a single mouse blastomere is described, which detected the expression of 75% more genes than microarray techniques and identified 1,753 previously unknown splice junctions called by at least 5 reads.
Journal ArticleDOI
Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children
Alexander Drilon,Theodore W. Laetsch,Shivaani Kummar,Steven G. DuBois,Ulrik Lassen,George D. Demetri,Michael J. Nathenson,Robert C. Doebele,Anna F. Farago,Alberto S. Pappo,Brian Turpin,Afshin Dowlati,Marcia S. Brose,Leo Mascarenhas,Noah Federman,Jordan Berlin,Wafik S. El-Deiry,Christina S. Baik,John F. Deeken,Valentina Boni,Ramamoorthy Nagasubramanian,Matthew H. Taylor,Erin R. Rudzinski,Funda Meric-Bernstam,Davendra Sohal,Patrick C. Ma,Luis E. Raez,Jaclyn F. Hechtman,Ryma Benayed,Marc Ladanyi,Brian B. Tuch,Kevin Ebata,Scott Cruickshank,Nora Ku,Michael C. Cox,Douglas S. Hawkins,David S. Hong,David S. Hong,David M. Hyman +38 more
TL;DR: Larotrectinib had marked and durable antitumor activity in patients with TRK fusion–positive cancer, regardless of the age of the patient or of the tumor type.
Journal ArticleDOI
The developmental transcriptome of Drosophila melanogaster
Brenton R. Graveley,Angela N. Brooks,Joseph W. Carlson,Michael O. Duff,Jane M. Landolin,Li Yang,Carlo G. Artieri,Marijke J. van Baren,Nathan Boley,Benjamin W. Booth,James B. Brown,Lucy Cherbas,Carrie A. Davis,Alexander Dobin,Renhua Li,Wei Lin,John H. Malone,Nicolas R. Mattiuzzo,David Scott Miller,David Sturgill,Brian B. Tuch,Brian B. Tuch,Chris Zaleski,Dayu Zhang,Marco Blanchette,Marco Blanchette,Sandrine Dudoit,Brian D. Eads,Richard E. Green,Ann S. Hammonds,Lichun Jiang,Phil Kapranov,Laura Langton,Norbert Perrimon,Jeremy E. Sandler,Kenneth H. Wan,Aarron T. Willingham,Yu Zhang,Yi Zou,Justen Andrews,Peter J. Bickel,Steven E. Brenner,Michael R. Brent,Peter Cherbas,Thomas R. Gingeras,Thomas R. Gingeras,Roger A. Hoskins,Thomas C. Kaufman,Brian Oliver,Susan E. Celniker +49 more
TL;DR: 111,195 new elements are identified, including thousands of genes, coding and non-coding transcripts, exons, splicing and editing events and inferred protein isoforms that previously eluded discovery using established experimental, prediction and conservation-based approaches.
Journal ArticleDOI
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution
TL;DR: It is proposed that the regulation of protein function by phosphorylation often depends on simple nonspecific mechanisms that disrupt or enhance protein-protein interactions and the gain or loss of phosphorylated sites in rapidly evolving regions could facilitate the evolution of kinase-signaling circuits.
Journal ArticleDOI
A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Clarissa J. Nobile,Emily P. Fox,Jeniel E. Nett,Trevor R. Sorrells,Quinn M. Mitrovich,Aaron D. Hernday,Brian B. Tuch,David R. Andes,Alexander D. Johnson +8 more
TL;DR: A master circuit controlling biofilm formation in the pathogenic yeast Candida albicans, composed of six transcription regulators that form a tightly woven network with ∼1,000 target genes, is described and analyzed.