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Adelheid Soubry
Researcher at Katholieke Universiteit Leuven
Publications - 24
Citations - 2060
Adelheid Soubry is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Epigenetics & Offspring. The author has an hindex of 17, co-authored 24 publications receiving 1688 citations. Previous affiliations of Adelheid Soubry include Duke University.
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Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
Adelheid Soubry,Joellen M. Schildkraut,Amy P. Murtha,Frances Wang,Zhiqing Huang,Autumn J. Bernal,Joanne Kurtzberg,Randy L. Jirtle,Susan K. Murphy,Cathrine Hoyo +9 more
TL;DR: The data indicate a preconceptional impact of paternal obesity on the reprogramming of imprint marks during spermatogenesis and suggest an increase in DNA methylation at the IGF2 and H19 DMRs among newborns from obese mothers, but a larger study is warranted to further explore the potential effects of maternal obesity or lifestyle on the offspring's epigenome.
Journal ArticleDOI
Newborns of obese parents have altered DNA methylation patterns at imprinted genes.
Adelheid Soubry,Susan K. Murphy,Frances Wang,Zhiqing Huang,Adriana C. Vidal,Bernard F. Fuemmeler,Joanne Kurtzberg,Amy P. Murtha,Randy L. Jirtle,Joellen M. Schildkraut,Cathrine Hoyo +10 more
TL;DR: A significant and independent association between paternal obesity and the offspring’s methylation status suggests the susceptibility of the developing sperm for environmental insults and altered methylation outcomes at multiple imprint regulatory regions in children born to obese parents, compared with childrenBorn to non-obese parents.
Journal ArticleDOI
A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
TL;DR: This essay suggests the existence of epigenetic windows of susceptibility to environmental insults during sperm development and suggests changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote.
Journal ArticleDOI
Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study
Adelheid Soubry,Lisa N. Guo,Zhiqing Huang,Cathrine Hoyo,Stephanie Romanus,Thomas M Price,Susan K. Murphy +6 more
TL;DR: The data support that male overweight/obesity status is traceable in the sperm epigenome, and set the groundwork for future studies investigating male gametic methylation aberrations due to paternal lifestyle factors such as obesity.
Journal ArticleDOI
Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States
Kate Hoffman,Craig M. Butt,Thomas F. Webster,Emma V. Preston,Stephanie C. Hammel,Colleen M. Makey,Amelia Lorenzo,Ellen M. Cooper,Courtney C. Carignan,John D. Meeker,Russ Hauser,Adelheid Soubry,Susan K. Murphy,Thomas M Price,Cathrine Hoyo,Emma Mendelsohn,Johanna Congleton,Julie L. Daniels,Heather M. Stapleton +18 more
TL;DR: In this paper, the authors combined data from 14 U.S. epidemiologic studies for which their laboratory group previously assessed exposure to two commonly used organophosphate compounds, tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP).