Prevention of what

Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.

https://www.mdpi.com/1420-3049/25/22/5243/pdf

Important Flavonoids and Their Role as a Therapeutic Agent.

A new strain of a novel infectious disease affecting millions of people, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently been declared as a pandemic by the World...

An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study.

Polyphenols and their applications: An approach in food chemistry and innovation potential.

A wide range of neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's disease, Huntington's disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, and inflammation. Intervention strategies using plant-derived bioactive compounds have been offered as a form of treatment for these debilitating conditions, as there are currently no remedies to prevent, reverse, or halt the progression of neuronal loss. Rutin, a glycoside of the flavonoid quercetin, is found in many plants and fruits, especially buckwheat, apricots, cherries, grapes, grapefruit, plums, and oranges. Pharmacological studies have reported the beneficial effects of rutin in many disease conditions, and its therapeutic potential in several models of NDs has created considerable excitement. Here, we have summarized the current knowledge on the neuroprotective mechanisms of rutin in various experimental models of NDs. The mechanisms of action reviewed in this article include reduction of proinflammatory cytokines, improved antioxidant enzyme activities, activation of the mitogen-activated protein kinase cascade, downregulation of mRNA expression of PD-linked and proapoptotic genes, upregulation of the ion transport and antiapoptotic genes, and restoration of the activities of mitochondrial complex enzymes. Taken together, these findings suggest that rutin may be a promising neuroprotective compound for the treatment of NDs.

/pdf/rutin-as-a-potent-antioxidant-implications-for-4675zjnkki.pdf

Rutin as a potent antioxidant: implications for neurodegenerative disorders

The contemporary scientific community has presently recognized flavonoids to be a unique class of therapeutic molecules due to their diverse therapeutic properties. Of these, rutin, also known as vitamin P or rutoside, has been explored for a number of pharmacological effects. Tea leaves, apples, and many more possess rutin as one of the active constituents. Today, rutin has been observed for its nutraceutical effect. The present review highlights current information and health-promoting effects of rutin. Along with this, safety pharmacology issues and SAR of the same have also been discussed.

The Pharmacological Potential of Rutin.

Protective effect of rutin on humoral and cell mediated immunity in rat model.

Protective effect of catechin on humoral and cell mediated immunity in rat model.

The modern scientific society has presently recognized flavonoids to be a unique class of therapeutic molecules due to their varied therapeutic properties. Of these, hesperidin, found along with vitamin C, has been explored for a number of pharmacological effects. Citrus and oranges possess hesperidin as one of the active constituents. Today, hesperidin has been well recognized for its beneficial effects on health. The present review highlights the current information and health-promoting effects of hesperidin. The review uncovers protective effects of hesperidin on functions and integrity of liver, kidney, heart, and age related memory impairment. Hesperidin demonstrated the antimicrobial, anticancer, antihypertensive and antiulcer effect. The present review focus on current information of hesperidin and its active metabolite hesperetin. Along with this, the chemotherapeutic potential of the same has also discussed.

/pdf/the-pharmacological-potential-of-hesperidin-2uchtvzpwg.pdf

The pharmacological potential of hesperidin

The use of plant products as immunomodulator has a long history. Forms eternal era, plant, mineral and animal products are used as drugs for the treatment of various diseases. The present-day synthetic compounds find their leads in natural products. The process of immunomodulation retunes the immune system of an individual by restoring routine functions. Research on immunomodulators from natural sources has been extensively studied for modulation of immune system along with protection and prevention of diseases. Rutin, a flavonoid has been investigated for its potential immunomodulatory effects. Increased particle clearance, decreased inflammation, increased leucocyte and antibody production was observed with administration of rutin in rats. The present study is focused on exploring in silico interaction of rutin with some chemokines and inflammatory targets. In this study, rutin was docked with TNF-α, IL-1β, IL-6, and NOs. Docking studies revealed the excellent interaction of rutin with these targets. The result of present study provides insight for the discovery of novel molecules for immunomodulation and treatment of inflammatory disorders. Findings from the present study show that rutin may interact with several chemokines and inflammatory mediators. Further studies on rutin and associated flavonoids are necessary to develop and establish QSAR and QSPR studies which may serve a stepping stone for the development of novel and safe immunomodulator. Rutin therefore, can be considered for development of an immunomodulatory agent.

/pdf/in-silico-interaction-of-catechin-with-some-immunomodulatory-3xjxj8ztj0.pdf

Aditya Ganeshpurkar

Papers

The Pharmacological Potential of Rutin.

Protective effect of rutin on humoral and cell mediated immunity in rat model.

Protective effect of catechin on humoral and cell mediated immunity in rat model.

The pharmacological potential of hesperidin

In silico interaction of catechin with some immunomodulatory targets: A docking analysis