Adriano T. Franzi

TL;DR: It is shown that corneal progenitor cells are localised in the limbus, that cultured limbal cells generate cohesive sheets of authentic cornean epithelium, and that autologous cultured corneals restored the corNEal surface of two patients with complete loss of the Corneal-limbus epithelio.

TL;DR: It is suggested that the basal keratinocyte is the cell synthesizing and secreting NGF in the human adult epidermis and might have a major role in regulating innervation, lymphocyte function, and melanocyte growth and differentiation in epidermal morphogenesis as well as during wound healing.

TL;DR: It is shown that (a) human keratinocytes and oral epithelial cells possess strong and specific melanocyte growth stimulating activity (doubling time, 24 h); (b) melanocytes growth is not autonomous but requires close keratinocyte contact and is regulated to maintain a physiological melanocytes/keratinocytes ratiol and (c) pure skin keratin cells have all the information required for the proper physiological location and differentiation of melanocytes in the epidermis.

TL;DR: It is demonstrated that palate-derived epithelial cells that were able to reconstitute a palatal epithelium can be successfully transplanted onto patients presenting lack of adherent keratinizing gingival mucosa and is able to fully express the differentiation program typical of the original donor site.

TL;DR: Treatment in cases ofHYPOSPADIAS requires extensive reconstruction of the anterior urethra, usually with autografts of flaps of contiguous skin or preputial skin transferred with a vascular pedicle.