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Advait S. Nagle
Researcher at University of South Florida
Publications - 17
Citations - 723
Advait S. Nagle is an academic researcher from University of South Florida. The author has contributed to research in topics: Alkylation & Alkyl. The author has an hindex of 9, co-authored 17 publications receiving 690 citations.
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Cesium effect: high chemoselectivity in direct N-alkylation of amines
TL;DR: The results demonstrated this methodology was highly chemoselective to favor mono-N-alkylation over dialkylation, offering wide applications in peptidomimetic syntheses.
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Efficient carbamate synthesis via a three-component coupling of an amine, CO2, and alkyl halides in the presence of Cs2CO3 and tetrabutylammonium iodide.
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Cesium Hydroxide Promoted Chemoselective N-Alkylation for the Generally Efficient Synthesis of Secondary Amines
TL;DR: In this paper, a selective N-alkylation of primary amines was developed using cesium hydroxide to prepare various secondary amines efficiently, and the preliminary results demonstrated that this methodology was highly chemoselective, favoring mono-N-alkylation over dialkylation.
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Gamma-lactam synthesis via C-H insertion: elaboration of N-benzyl protecting groups for high regioselectivity toward the total synthesis of rolipram.
TL;DR: By intramolecular C-H insertion of alpha-diazo-alpha-(phenylsulfonyl)acetamides, gamma-lactams such as the antidepressant agent rolipram were efficiently synthesized in a highly regioselective manner.
Journal ArticleDOI
Efficient Cs2CO3-promoted solution and solid phase synthesis of carbonates and carbamates in the presence of TBAI
Ralph N. Salvatore,Feixia Chu,Advait S. Nagle,Elona A. Kapxhiu,Richard M. Cross,Kyung Woon Jung +5 more
TL;DR: In this article, a solution and solid-phase method for the synthesis of carbonates and carbamates using cesium bases and TBAI via a three-component coupling was developed.