A
Agathe Lafont
Publications - 1
Citations - 1
Agathe Lafont is an academic researcher. The author has contributed to research in topics: Exome sequencing & Proband. The author has an hindex of 1, co-authored 1 publications receiving 1 citations.
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The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.
Margaret F. Lippincott,Wanxue Xu,Abigail A Smith,Xinyu Miao,Agathe Lafont,Omar Shennib,Gordon J Farley,Riwa Sabbagh,Angela Delaney,Marianna Stamou,Lacey Plummer,Kathryn B Salnikov,Neoklis A. Georgopoulos,Verónica Mericq,Richard Quinton,Frédéric Tran Mau-Them,Sophie Nambot,Asma Hamad,Helen Brittain,Rebecca S. Tooze,Eduardo Calpena,Andrew O.M. Wilkie,Marjolaine Willems,William F. Crowley,Ravi Balasubramanian,Nathalie Lamarche-Vane,Erica E. Davis,Stephanie B. Seminara +27 more
TL;DR: ARSGAP35 is identified as a new autosomal dominant genetic driver for IHH and ARHGAP5 as a candidate gene for I HH, and observations suggest a novel role for the p190 RhoGAP proteins in GnRH neuronal development and integrity.