R
Ravi Balasubramanian
Publications - 12
Citations - 27
Ravi Balasubramanian is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 7 citations.
Papers
More filters
Journal ArticleDOI
Prevalence and Phenotypic Effects of Copy Number Variants in Isolated Hypogonadotropic Hypogonadism.
Marianna Stamou,Harrison Brand,Mei Wang,Isaac Wong,Margaret F. Lippincott,Lacey Plummer,William F. Crowley,Michael E. Talkowski,Stephanie B. Seminara,Ravi Balasubramanian +9 more
TL;DR: Syndromic phenotypes resulting from single gene CNVs validate pleiotropy of some IHH genes and are needed to identify novel genes and/or other elusive variants that may explain the remaining missing etiology of IHH.
Journal ArticleDOI
MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes
TL;DR: Using a bioinformatics approach, the authors identify several miR-7a2–regulated genes involved in reproductive hormone biosynthesis pathways and provide a framework for future studies aimed at understanding rare reproductive conditions.
Journal ArticleDOI
Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans
Katerina Hoskova,Nora Kayton Bryant,Margaret E. Chen,Lisa B. Nachtigall,Margaret F. Lippincott,Ravi Balasubramanian,Stephanie B. Seminara +6 more
TL;DR: Kisspeptin is capable of stimulating hypothalamic GnRH-induced LH pulses in the setting of hyperprolactinemia, and this work found that 73% of subjects exhibited an LH pulse within 30 minutes of first kisspeptin dose.
Journal ArticleDOI
Reproductive phenotypes and genotypes in men with IHH.
Andrew A. Dwyer,Marianna Stamou,Elena Anghel,Shira B. Hornstein,Danna Chen,Kathryn B Salnikov,Isabella R. McDonald,Lacey Plummer,Stephanie B. Seminara,Ravi Balasubramanian +9 more
TL;DR: Variable phenotypic severity in the face of severe genetic variants in other IHH genes point to significant neuroendocrine plasticity of the HPG axis in IHH men.
Journal ArticleDOI
The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.
Margaret F. Lippincott,Wanxue Xu,Abigail A Smith,Xinyu Miao,Agathe Lafont,Omar Shennib,Gordon J Farley,Riwa Sabbagh,Angela Delaney,Marianna Stamou,Lacey Plummer,Kathryn B Salnikov,Neoklis A. Georgopoulos,Verónica Mericq,Richard Quinton,Frédéric Tran Mau-Them,Sophie Nambot,Asma Hamad,Helen Brittain,Rebecca S. Tooze,Eduardo Calpena,Andrew O.M. Wilkie,Marjolaine Willems,William F. Crowley,Ravi Balasubramanian,Nathalie Lamarche-Vane,Erica E. Davis,Stephanie B. Seminara +27 more
TL;DR: ARSGAP35 is identified as a new autosomal dominant genetic driver for IHH and ARHGAP5 as a candidate gene for I HH, and observations suggest a novel role for the p190 RhoGAP proteins in GnRH neuronal development and integrity.