A
Agnes Görlach
Researcher at Technische Universität München
Publications - 94
Citations - 8411
Agnes Görlach is an academic researcher from Technische Universität München. The author has contributed to research in topics: NADPH oxidase & Hypoxia-inducible factors. The author has an hindex of 46, co-authored 91 publications receiving 7325 citations.
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Journal ArticleDOI
Calcium and ROS: A mutual interplay.
TL;DR: Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks.
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The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control.
TL;DR: Redox homeostasis appears to be a prerequisite for proper functioning of the ER, and a close relationship exists between oxidative stress and ER stress, which both may activate signaling events leading to a rebalance of folding capacity and folding demand or to cell death.
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Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site.
Steve Bonello,Christian Zähringer,Rachida S. BelAiba,Talija Djordjevic,John R. Hess,Carine Michiels,Thomas Kietzmann,Agnes Görlach +7 more
TL;DR: It is shown for the first time to the authors' knowledge that reactive oxygen species directly link HIF-1&agr; and NF-&kgr;B, implicating an important pathophysiological role of this novel pathway in disorders associated with elevated levels of reactive oxygen Species.
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Hypoxia Up-Regulates Hypoxia-Inducible Factor-1α Transcription by Involving Phosphatidylinositol 3-Kinase and Nuclear Factor κB in Pulmonary Artery Smooth Muscle Cells
Rachida S. BelAiba,Steve Bonello,Christian Zähringer,Stefanie Schmidt,John Hess,Thomas Kietzmann,Agnes Görlach +6 more
TL;DR: A novel mechanism in which hypoxia induces HIF-1alpha mRNA expression via the PI3K/AKT pathway and activation of NFkappaB is provided.
Journal ArticleDOI
Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression
Thomas Kietzmann,Agnes Görlach +1 more
TL;DR: The role of ROS in the regulation of HIF-1 under Hypoxia-inducible transcription factors under hypoxic and non-hypoxic conditions is summarized.