Agnes J. Bishop

TL;DR: Severe thromboses and hemorrhages occurred in 18 children receiving vincristine, prednisone, and asparaginase therapy for ALL, with symptoms of headache, obtundation, hemiparesis, and seizure common for the intracranial events.

TL;DR: A family with an inherited bleeding disorder extending over four generations, and multiple cases of myeloblastic and myelomonoblastic leukaemia was studied, finding that the number of dense granules was decreased by immunofluorescence employing quinacrine or using an antibody to the dense granule membrane protein, granulophysin, confirming an absolute decrease in densegranule numbers.

TL;DR: This experience and the observation that GH deficiency was diagnosed in fewer than 1% of children with histiocytosis in Canada during a 15-year period suggest that classic GH deficiency is not a common complication of histiocytes unless direct hypothalamic-pituitary irradiation has been given.

TL;DR: Using the post-DDAVP instead of the standard FVIIIc/FVIII R:Ag ratio, hemophilia carrier detection was increased from 85% (with 10% false positive and 20% false negative assignments) to 95% ( with 5%False positive and 5%false negative assignments).

TL;DR: The observations suggest the fibrinolytic system of the fetus is inefficient compared with that of the adult; this could be a considerable disadvantage in the presence of intravascular coagulation.