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Ahuva Itin
Researcher at Hebrew University of Jerusalem
Publications - 41
Citations - 14242
Ahuva Itin is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Vascular endothelial growth factor & Vascular endothelial growth factor A. The author has an hindex of 27, co-authored 41 publications receiving 13893 citations.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
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Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity.
TL;DR: It is shown that regression of retinal capillaries in neonatal rats exposed to high oxygen, is preceded by a shut–off of vascular endothelial growth factor (VEGF) production by nearby neuroglial cells.
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Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
TL;DR: It is shown that blood vessels in both a xenografted tumor and primary human tumors contain a sizable fraction of immature blood vessels that have not yet recruited periendothelial cells, suggesting that the unique dependence on VEGF of blood vessels lacking periENDothelial Cells can be exploited to reduce an existing tumor vasculature.
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VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
Myriam Grunewald,Inbal Avraham,Yuval Dor,Esther Bachar-Lustig,Ahuva Itin,Steffen Yung,Stephano Chimenti,Limor Landsman,Rinat Abramovitch,Eli Keshet +9 more
TL;DR: The data suggest a model for VEGF-programmed adult neovascularization highlighting the essential paracrine role of recruited myeloid cells and a role for SDF1 in their perivascular retention.
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Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.
TL;DR: It is shown that expression of vascular endothelial growth factor (VEGF) is upregulated in chronically hypoxic niches (inner layers) of the spheroid and that expression is reversed when hypoxia is relieved by hyperoxygenation and that stress-induced VEGF activity is taken into account in any attempt to target tumor angiogenesis.