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Dorit Shweiki
Researcher at Hebrew University of Jerusalem
Publications - 13
Citations - 7226
Dorit Shweiki is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Vascular endothelial growth factor & Vascular endothelial growth factor A. The author has an hindex of 8, co-authored 13 publications receiving 7082 citations. Previous affiliations of Dorit Shweiki include Tel Aviv University.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
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Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.
TL;DR: It is shown that expression of vascular endothelial growth factor (VEGF) is upregulated in chronically hypoxic niches (inner layers) of the spheroid and that expression is reversed when hypoxia is relieved by hyperoxygenation and that stress-induced VEGF activity is taken into account in any attempt to target tumor angiogenesis.
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Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.
TL;DR: It is proposed that excessive expression of VEGF during gonadotropin-induced ovulation may contribute to the development of ovarian hyperstimulation syndromes by virtue of the vascular permeabilization activity of this factor.
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Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes.
TL;DR: Two different consequences of tissue ischemia, namely, hypoxia and glucose deprivation, induce VEGF and GLUT-1 expression by similar mechanisms, which function, in turn, to satisfy the tissue needs through expanding its vasculature and improving its glucose utilization, respectively.
Journal Article
Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases
TL;DR: In situ hybridization techniques were used to examine the thesis that VEGF functions as the link between retinal ischemia and a pathologic, intraocular, angiogenic response to promote retinal and iris neovascularization in a number of neov vascular eye diseases.