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Aifen Yang
Researcher at Hangzhou Normal University
Publications - 17
Citations - 89
Aifen Yang is an academic researcher from Hangzhou Normal University. The author has contributed to research in topics: Oligodendrocyte & Myelin. The author has an hindex of 4, co-authored 12 publications receiving 38 citations.
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Journal ArticleDOI
TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway
Yidan Chen,Ruyi Mei,Peng Teng,Aifen Yang,Xuemei Hu,Zunyi Zhang,Mengsheng Qiu,Mengsheng Qiu,Xiaofeng Zhao +8 more
TL;DR: It is reported that TAPP1 was selectively expressed in differentiating OL precursor cells (OPCs) and identified as an important negative regulator of OPC differentiation through the Mek/Erk signaling pathway.
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Theabrownin Induces Cell Apoptosis and Cell Cycle Arrest of Oligodendroglioma and Astrocytoma in Different Pathways.
J. Y. Fu,C. X. Jiang,M. Y. Wu,R. Y. Mei,Aifen Yang,Huaping Tao,Xiongying Chen,Jian Zhang,Lei Huang,Xiaofeng Zhao +9 more
TL;DR: In this article, the effect of green tea on glioma cells was investigated, and TB significantly reduced the viabilities of HOG and U251 cells in a dose-dependent manner, which was accompanied by the upregulation of active-Casp-3, Bax, and PTEN.
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S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS.
TL;DR: In this paper, the authors provide several lines of molecular and genetic evidences that S100B is expressed in both protoplasmic and myelinating oligodendrocytes.
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AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination
Chunxia Jiang,Wanqing Yang,Zhihong Fan,Peng Teng,Ruyi Mei,Junlin Yang,Aifen Yang,Mengsheng Qiu,Mengsheng Qiu,Xiaofeng Zhao +9 more
TL;DR: It is found that an axonal outgrowth regulatory molecule, AATYK (apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination and is essential for the differentiation of OLs.
Journal ArticleDOI
Stage-specific regulation of oligodendrocyte development by Hedgehog signaling in the spinal cord.
Xiaofeng Xu,Qian Yu,Minxi Fang,Min Yi,Aifen Yang,Binghua Xie,Junlin Yang,Zunyi Zhang,Zhong-Min Dai,Mengsheng Qiu,Mengsheng Qiu +10 more
TL;DR: The present study systematically investigated OPC specification and differentiation in genetically modified mouse models of Smoothened (Smo), an essential component of the Hh signaling pathway in vertebrates, and uncovered the stage‐specific regulation of OL development by Smo‐mediated HH signaling, providing novel insights into the molecularregulation of OL differentiation and myelin repair.