Xuemei Hu

TL;DR: In this study, in vivo evidence for a late phase of Olig gene expression independent of Nkx6 and Shh gene activities is provided and a brief second wave of oligodendrogenesis in the dorsal spinal cord is revealed.

TL;DR: Evidence is presented that the control of oligodendrocyte differentiation by Olig2, Sox10 and Nkx2.2 is a dosage-dependent developmental process and can be affected by both haploinsufficiency and over-dosage.

TL;DR: It is demonstrated that activation of β-catenin in neural progenitor cells before gliogenesis inhibits the generation of oligodendrocyte progenitors (OLPs) in mice, and this findings suggest that Wnt/β-Catenin pathway regulates oligod endocrine development in a stage-dependent manner.

TL;DR: The developmental origin of postnatal spinal ependymal cells is investigated by studying the dynamic expression of several neural progenitor genes that are initially expressed in distinct domains of neuroepithelium in young embryos by suggesting that the Nkx6.1+ ventral neuroep ithelial cells in adult mouse spinal cords may retain the proliferative property of neural stem cells.

TL;DR: In vivo studies revealed that disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that NeCl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNSmyelination.