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Aijaz A. John
Researcher at Central Drug Research Institute
Publications - 26
Citations - 377
Aijaz A. John is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Osteoblast & Wnt signaling pathway. The author has an hindex of 9, co-authored 23 publications receiving 262 citations. Previous affiliations of Aijaz A. John include Central University of Punjab & Council of Scientific and Industrial Research.
Papers
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Journal ArticleDOI
Biocompatible fluorescent carbon quantum dots prepared from beetroot extract for in vivo live imaging in C. elegans and BALB/c mice
Vikram Singh,Kundan S. Rawat,Kundan S. Rawat,Shachi Mishra,Tanvi Baghel,Soobiya Fatima,Soobiya Fatima,Aijaz A. John,Navodayam Kalleti,Divya Singh,Divya Singh,Aamir Nazir,Aamir Nazir,Srikanta Kumar Rath,Srikanta Kumar Rath,Atul Goel,Atul Goel +16 more
TL;DR: In this paper, luminous carbon quantum dots (CQDs) prepared from aqueous beetroot extract were developed as unique fluorescent nanomaterials for in vivo live animal imaging applications.
Journal Article
Biocompatible fluorescent carbon quantum dots prepared from beetroot extract for in vivo live imaging in C. elegans and BALB/c mice
Kundan S. Rawat,Shachi Mishra,Tanvi Baghel,Soobiya Fatima,Aijaz A. John,Navodayam Kalleti,Divya Singh,Aamir Nazir,Srikanta Kumar Rath,Atul Goel +9 more
TL;DR: The in vivo imaging and toxicity evaluation of blue and green emitting environmentally benign CQDs were performed for the first time in the Caenorhabditis elegans model, which revealed consistent fluorescence in the gut tissues of the worms without exerting any sign of toxic effects on the nematodes.
Journal ArticleDOI
Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways.
Manisha Dixit,Ashutosh Raghuvanshi,Chandra Prakash Gupta,Jyoti Kureel,Mohd Nizam Mansoori,Priyanka Shukla,Aijaz A. John,Kavita Singh,Dipak Purohit,Pallavi Awasthi,Divya Singh,Atul Goel +11 more
TL;DR: It was observed that med promoted bone regeneration by activating canonical Wnt and notch signaling pathway in cortical bone defect model that heals by intramembranous ossification, and confirmed that med treatment leads to elevated bone healing in pre-osteoblasts by co localization of beta catenin with osteoblast marker alkaline phosphatase.
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MiR 376c inhibits osteoblastogenesis by targeting Wnt3 and ARF-GEF-1 -facilitated augmentation of beta-catenin transactivation.
TL;DR: This work shows that miR‐376c, a well‐characterized tumor suppressor which inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor‐alpha, suppresses osteoblast proliferation, and differentiation, and targets Wnt‐3 and ARF‐GEF‐1.
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Identification of novel microRNA inhibiting actin cytoskeletal rearrangement thereby suppressing osteoblast differentiation
TL;DR: Overall, miR-1187 functions as a negative regulator of osteogenesis by repressing BMPR-II and ArhGEF-9 expression thus suppressing non-Smad BMP2/Cdc42 signaling pathway and inhibiting actin reorganization.