J
Jyoti Kureel
Researcher at Central Drug Research Institute
Publications - 13
Citations - 343
Jyoti Kureel is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Osteoblast & Ovariectomized rat. The author has an hindex of 8, co-authored 13 publications receiving 262 citations.
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Journal ArticleDOI
miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation
Jyoti Kureel,Manisha Dixit,Abdul Malik Tyagi,Mohd Nizam Mansoori,Kamini Srivastava,Ashutosh Raghuvanshi,Rakesh Maurya,Ritu Trivedi,Atul Goel,Divya Singh +9 more
TL;DR: It is shown that miR-542-3p, a well-characterized tumor suppressor whose downregulation is tightly associated with tumor progression via C-src-related oncogenic pathways, inhibits osteoblast proliferation and differentiation and inhibits BMP-7-mediated osteogenesis.
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IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation.
Mohd Nizam Mansoori,Priyanka Shukla,Manisha Kakaji,Abdul Malik Tyagi,Kamini Srivastava,Manoj Kumar Shukla,Manisha Dixit,Jyoti Kureel,Sushil Gupta,Divya Singh +9 more
TL;DR: In this paper, the role of IL-18BP on osteoblasts was investigated in post menopausal osteoporosis, and the effect of humanized IL18BPd on various immune and skeletal parameters.
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Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways.
Manisha Dixit,Ashutosh Raghuvanshi,Chandra Prakash Gupta,Jyoti Kureel,Mohd Nizam Mansoori,Priyanka Shukla,Aijaz A. John,Kavita Singh,Dipak Purohit,Pallavi Awasthi,Divya Singh,Atul Goel +11 more
TL;DR: It was observed that med promoted bone regeneration by activating canonical Wnt and notch signaling pathway in cortical bone defect model that heals by intramembranous ossification, and confirmed that med treatment leads to elevated bone healing in pre-osteoblasts by co localization of beta catenin with osteoblast marker alkaline phosphatase.
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Synthesis, optical resolution, absolute configuration, and osteogenic activity of cis-pterocarpans
Atul Goel,Amit Kumar,Yasmin Hemberger,Ashutosh Raghuvanshi,Ram Jeet,Govind Tiwari,Michael Knauer,Jyoti Kureel,Anuj Kumar Singh,Abnish K. Gautam,Ritu Trivedi,Divya Singh,Gerhard Bringmann +12 more
TL;DR: A comparative mechanism study for osteogenic (bone forming) activity of medicarpin revealed that (+)-(6aS,11aS)-medicarpin (6a) significantly increased the bone morphogenetic protein-2 expression and the level of the bone-specific transcription factor Runx-2 mRNA, while the effect was opposite for the other enantiomer.
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Identification of novel microRNA inhibiting actin cytoskeletal rearrangement thereby suppressing osteoblast differentiation
TL;DR: Overall, miR-1187 functions as a negative regulator of osteogenesis by repressing BMPR-II and ArhGEF-9 expression thus suppressing non-Smad BMP2/Cdc42 signaling pathway and inhibiting actin reorganization.