Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined. Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

http://ir.yic.ac.cn/bitstream/133337/17045/1/Molecular%20imprinting%20perspectives%20and%20applications.pdf

Molecular imprinting: perspectives and applications

Molecularly imprinted polymers are synthetic receptors for a targeted molecule. As such, they are analogues of the natural antibody–antigen systems. In this review, after a recounting of the early history of the general field, we specifically focus on the application of these polymers as sensors. In these applications, the polymers are paired with a reporting system, which may be electrical, electrochemical, optical, or gravimetric. The presence of the targeted molecule effects a change in the reporting agent, and a calibrated quantity of the target is recorded. In this review, we describe the imprinted polymer production processes, the techniques used for reporting, and the applications of the reported sensors. A brief survey of recent applications to gas-phase sensing is included, but the focus is primarily on the development of sensors for targets in solution. Included among the applications are those designed to detect toxic chemicals, toxins in foods, drugs, explosives, and pathogens. The application...

Molecularly Imprinted Polymers

The current application of nanotechnology in food and agriculture.

Herein, we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004-2011. In total, 3779 references to the original papers, rev ...

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011.

Sample preparation is a crucial bottleneck in the whole analytical process. Solid-phase sorbents (SPSs) have aroused increasing interest in research on sample preparation, as they have key roles in obtaining high clean-up and enrichment efficiency in the analysis of trace targets present in complex matrices. The objective of this review is to provide a broad overview of the recent advances and applications of SPSs in sample preparation prior to chromatographic analysis, during the period 2008-13. We include SPSs, such as molecularly-imprinted polymers, carbon nanomaterials, metallic nanoparticles and metal organic frameworks, focusing on solid-phase extraction, solid-phase microextraction, matrix solid-phase dispersion and stir-bar sorptive extraction of typical pollutants in environmental, biological, food and pharmaceutical samples. We propose remaining challenges and future perspectives to improve development of new SPSs and to apply them further. (C) 2014 Elsevier B.V. All rights reserved.

Recent advances in solid-phase sorbents for sample preparation prior to chromatographic analysis

Group-selective molecularly imprinted polymer solid-phase extraction for the simultaneous determination of six sulfonamides in aquaculture products.

Development and application of a novel fluorescent nanosensor based on FeSe quantum dots embedded silica molecularly imprinted polymer for the rapid optosensing of cyfluthrin

Group-selective enrichment and determination of pyrethroid insecticides in aquaculture seawater via molecularly imprinted solid phase extraction coupled with gas chromatography-electron capture detection.

A new type of molecularly imprinted silica layers appended to quantum dots (MIP-QDs) for saxitoxin (STX) was fabricated through the surface grafting technique. The MIP-QDs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FT-IR), and imprinting and selective fluorescence quenching properties in different solutions. Results demonstrated that the synthesized MIP-QDs exhibited excellent selective fluorescence quenching to STX because of the complementary imprinted cavities on the surface of MIP-QDs. Furthermore, a fluorescence nanosensor based on MIP-QDs was fabricated for the selective detection of STX under optimal experimental conditions. A good linear relationship in the range of 20.0-100.0 μg/L with a correlation coefficient of 0.9988 was obtained. Excellent recoveries ranging from 89.4% to 102.4% with the RSD below 6.3% were obtained for the shellfish samples at three spiked levels of STX. The detection limit of STX in shellfish samples was 0.3 μg/kg. The results indicated that the developed fluorescence nanosensor was highly selective and sensitive enough to detect STX in shellfish samples.

Development of a selective fluorescence nanosensor based on molecularly imprinted-quantum dot optosensing materials for saxitoxin detection in shellfish samples

Selective and sensitive determination of cypermethrin in fish via enzyme-linked immunosorbent assay-like method based on molecularly imprinted artificial antibody-quantum dot optosensing materials

Aili Sun

Papers

Group-selective molecularly imprinted polymer solid-phase extraction for the simultaneous determination of six sulfonamides in aquaculture products.

Development and application of a novel fluorescent nanosensor based on FeSe quantum dots embedded silica molecularly imprinted polymer for the rapid optosensing of cyfluthrin

Group-selective enrichment and determination of pyrethroid insecticides in aquaculture seawater via molecularly imprinted solid phase extraction coupled with gas chromatography-electron capture detection.

Development of a selective fluorescence nanosensor based on molecularly imprinted-quantum dot optosensing materials for saxitoxin detection in shellfish samples

Selective and sensitive determination of cypermethrin in fish via enzyme-linked immunosorbent assay-like method based on molecularly imprinted artificial antibody-quantum dot optosensing materials