Å
Åke Seiger
Researcher at Karolinska Institutet
Publications - 266
Citations - 17503
Åke Seiger is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Spinal cord & Transplantation. The author has an hindex of 64, co-authored 261 publications receiving 16884 citations. Previous affiliations of Åke Seiger include University of Colorado Hospital & St. Elizabeth Hospital.
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Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system
TL;DR: Fetal rat dopamine-containg neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed to suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue.
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Late prenatal ontogeny of central monoamine neurons in the rat: Fluorescence histochemical observations
Åke Seiger,Lars Olson +1 more
TL;DR: It is concluded that the monoamine-neurons develop mechanisms for synthesis and storage of amines at a very early stage during ontogeny, thus recapitulating the phylogeny of these old systems.
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Transplantation of adrenal medullary tissue to striatum in parkinsonism. First clinical trials.
Erik-Olof Backlund,Per-Ola Granberg,Bertil Hamberger,Evert Knutsson,Anders Mårtensson,Göran Sedvall,Åke Seiger,Lars Olson +7 more
TL;DR: Autologous adrenal medullary tissue was transplanted to the striatum in two patients with severe parkinsonism to provide thestriatum with a new cellular source of catecholamines, the first time such tissue has been transplanted in the human brain.
Journal ArticleDOI
In vitro expansion of a multipotent population of human neural progenitor cells.
Melissa K. Carpenter,Xia Cui,Zhong-yi Hu,Jennifer A. Jackson,Sandy S. Sherman,Åke Seiger,Lars Wahlberg +6 more
TL;DR: The results demonstrate the feasibility of long-term in vitro expansion of human neural progenitor cells and the ability to provide an expandable, well-characterized, defined cell source which can form specific neuronal or glial subtypes.
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Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up
Olle Lindvall,S Rehncrona,Patrik Brundin,Björn Gustavii,Birger Åstedt,Hạkan Widner,Tore Lindholm,Anders Björklund,Klaus L. Leenders,John C. Rothwell,Richard S. J. Frackowiak,C. David Marsden,Bo Johnels,Göran Steg,Robert Freedman,Barry J. Hoffer,Åke Seiger,Marc Bygdeman,Ingrid Strömberg,Lars Olson +19 more
TL;DR: The results suggest that the fetal nigral implants may have provided a modest improvement in motor function, consistent with the presence of small surviving grafts, in two patients with advanced Parkinson's disease.