Akhteruzzaman Molla

TL;DR: Analysis of the HIV protease gene from the plasma of HIV–infected patients revealed substitutions at nine different codons selected in response to monotherapy with the protease inhibitors ritonavir, suggesting that dual protease inhibitor therapy might increase the duration of viral suppression.

TL;DR: Viral RNA determinations at intermediate timepoints may be prognostic of impending virologic failure of protease inhibitor therapy and strategies that allow intensification of initial antiretroviral regimens in the subset of patients with incomplete virological response should be investigated.

TL;DR: Constant concentration-dependent autoinduction is the most likely mechanism for the time-dependent pharmacokinetics of ritonavir, and the levels were correlated with baseline triglyceride levels and AUC, Cmax, or predose concentrations.

TL;DR: The identification of resistance-associated mutations in both chimpanzees is consistent with the findings of in vitro selection studies, in which many of the same mutations were selected.

TL;DR: It is demonstrated that patient sequence heterogeneity affects replication efficiency whenever patient-derived NS5A-5B genes are inserted into the laboratory-optimized replicon.