R
Robert E. Lanford
Researcher at Texas Biomedical Research Institute
Publications - 118
Citations - 10526
Robert E. Lanford is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Virus & Hepatitis C virus. The author has an hindex of 51, co-authored 118 publications receiving 9863 citations. Previous affiliations of Robert E. Lanford include University of Texas Health Science Center at San Antonio.
Papers
More filters
Journal ArticleDOI
Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
Robert E. Lanford,Elisabeth S. Hildebrandt-Eriksen,Andreas Petri,Robert Persson,Morten Lindow,Martin E. Munk,Sakari Kauppinen,Sakari Kauppinen,Henrik Ørum +8 more
TL;DR: Treatment of chronically infected chimpanzees with a locked nucleic acid (LNA)–modified oligonucleotide (SPC3649) complementary to miR-122 leads to long-lasting suppression of HCV viremia, with no evidence of viral resistance or side effects in the treated animals.
Journal ArticleDOI
A pathogenic picornavirus acquires an envelope by hijacking cellular membranes
Zongdi Feng,Lucinda L. Hensley,Kevin L. McKnight,Fengyu Hu,Victoria J. Madden,Lifang Ping,Sook Hyang Jeong,Christopher J. Walker,Robert E. Lanford,Stanley M. Lemon +9 more
TL;DR: It is shown that HAV released from cells is cloaked in host-derived membranes, thereby protecting the virion from antibody-mediated neutralization, and blurs the classic distinction between ‘enveloped’ and ‘non-envelope’ viruses and has broad implications for mechanisms of viral egress from infected cells as well as host immune responses.
Journal ArticleDOI
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
Brett D. Lindenbach,Philip Meuleman,Alexander Ploss,Thomas Vanwolleghem,Andrew J. Syder,Jane A. McKeating,Robert E. Lanford,Stephen M. Feinstone,Marian E. Major,Geert Leroux-Roels,Charles M. Rice +10 more
TL;DR: It is reported here that HCVcc strain FL-J6/JFH can establish long-term infections in chimpanzees and in mice containing human liver grafts, and virus recovered from these animals was highly infectious in cell culture, demonstrating efficient ex vivo culture of HCV.
Journal ArticleDOI
DNA Microarray Analysis of Chimpanzee Liver during Acute Resolving Hepatitis C Virus Infection
TL;DR: The data suggest a biphasic mechanism of viral clearance dependent on both the innate and adaptive immune responses and provide insight into the response of the liver to a hepatotropic viral infection.
Journal ArticleDOI
GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees
Robert E. Lanford,Bernadette Guerra,Deborah Chavez,Luis D. Giavedoni,Vida L. Hodara,Kathleen M. Brasky,Abigail Fosdick,Christian R. Frey,Jim Zheng,Grushenka H.I. Wolfgang,Randall L. Halcomb,Daniel B. Tumas +11 more
TL;DR: The small molecule GS-9620 activates Toll-like receptor 7 signaling in immune cells of chimpanzees to induce clearance of HBV-infected cells and might be developed for treatment of patients with chronic HBV infection.