A
Aki Komatsu
Researcher at Chiba University
Publications - 14
Citations - 583
Aki Komatsu is an academic researcher from Chiba University. The author has contributed to research in topics: Cancer & Genetic enhancement. The author has an hindex of 10, co-authored 13 publications receiving 508 citations.
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Journal ArticleDOI
Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma
Nobuyoshi Takeshita,Isamu Hoshino,Mikito Mori,Yasunori Akutsu,Naoyuki Hanari,Yasuo Yoneyama,Norimasa Ikeda,Yuka Isozaki,Tetsurou Maruyama,Naoki Akanuma,Aki Komatsu,M Jitsukawa,Hiromasa Matsubara +12 more
TL;DR: These data support the contention that serum miR-1246 has strong potential as a novel diagnostic and prognostic biomarker in ESCC, and its releasing mechanism is selective and independent of tissue miRNA abundance.
Journal ArticleDOI
Quantification of plasma exosome is a potential prognostic marker for esophageal squamous cell carcinoma.
Yasunori Matsumoto,Masayuki Kano,Yasunori Akutsu,Naoyuki Hanari,Isamu Hoshino,Kentaro Murakami,Akihiro Usui,Hiroshi Suito,Masahiko Takahashi,Ryota Otsuka,Hu Xin,Aki Komatsu,Keiko Iida,Hisahiro Matsubara +13 more
TL;DR: Exosome levels may be useful as an independent prognostic factor for ESCC patients and quantification of exosomes in patient plasma as a biomarker for esophageal squamous cell carcinoma was assessed.
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Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of c-myc suppression by interferon-gamma in situ.
Kazuyuki Matsushita,Toshinao Takenouchi,Hideaki Shimada,Takeshi Tomonaga,Hideki Hayashi,Ayumi Shioya,Aki Komatsu,Hisahiro Matsubara,Takenori Ochiai +8 more
TL;DR: IFN‐γ, which induces HLA‐DR antigens on the cell surface, also suppresses c‐myc expression in situ, and is a possible non‐immunological mechanism involved in the better long‐term survival of colorectal cancer patients.
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Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice.
Yasunori Akutsu,Hisahiro Matsubara,Tetsuro Urashima,Aki Komatsu,Haruhito Sakata,Takanori Nishimori,Yasuo Yoneyama,Isamu Hoshino,Kentaro Murakami,Akihiro Usui,Masayuki Kano,Takenori Ochiai +11 more
TL;DR: A combination of direct intratumoral (i.t.) administration of dendritic cells (DCs) and radiation therapy (RT) in mouse squamous cell carcinoma and the functions of gp96, which can enhance systemic antitumor activity, and the mechanism of the abscopal effect are evaluated.
Journal ArticleDOI
ZNF750 Expression Is a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma.
Ryota Otsuka,Yasunori Akutsu,Haruhito Sakata,Naoyuki Hanari,Kentaro Murakami,Masayuki Kano,Takeshi Toyozumi,Masahiko Takahashi,Yasunori Matsumoto,Nobufumi Sekino,Masaya Yokoyama,Koichiro Okada,Tadashi Shiraishi,Aki Komatsu,Keiko Iida,Hisahiro Matsubara +15 more
TL;DR: The low expression of ZNF750 was significantly associated with a poor prognosis, and ZNF 750 expression may, therefore, be a reliable prognostic biomarker in ESCC.