N
Naoki Akanuma
Researcher at Chiba University
Publications - 28
Citations - 875
Naoki Akanuma is an academic researcher from Chiba University. The author has contributed to research in topics: Cancer & Gene knockdown. The author has an hindex of 13, co-authored 24 publications receiving 778 citations.
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Journal ArticleDOI
Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma
Nobuyoshi Takeshita,Isamu Hoshino,Mikito Mori,Yasunori Akutsu,Naoyuki Hanari,Yasuo Yoneyama,Norimasa Ikeda,Yuka Isozaki,Tetsurou Maruyama,Naoki Akanuma,Aki Komatsu,M Jitsukawa,Hiromasa Matsubara +12 more
TL;DR: These data support the contention that serum miR-1246 has strong potential as a novel diagnostic and prognostic biomarker in ESCC, and its releasing mechanism is selective and independent of tissue miRNA abundance.
Journal ArticleDOI
The overall prevalence of metastasis in T1 esophageal squamous cell carcinoma: a retrospective analysis of 295 patients
Yasunori Akutsu,Masaya Uesato,Kiyohiko Shuto,Tsuguaki Kono,Isamu Hoshino,Daisuke Horibe,Testutaro Sazuka,Nobuyoshi Takeshita,Tetsuro Maruyama,Yuka Isozaki,Naoki Akanuma,Hisahiro Matsubara +11 more
TL;DR: This study provides a precise assessment of the comprehensive risk of metastasis and feasible predictive markers for T1 ESCC.
Journal ArticleDOI
MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCN1 and MMP14, in esophageal cancer
Naoki Akanuma,Isamu Hoshino,Yasunori Akutsu,Kentarou Murakami,Yuka Isozaki,Tetsurou Maruyama,Gulbostan Yusup,Wei Qin,Takeshi Toyozumi,Masahiko Takahashi,Hiroshi Suito,Xin Hu,Nobufumi Sekino,Hiromasa Matsubara +13 more
TL;DR: The combined expression of FSCN1 and MMP14 is associated with a poor prognosis, and miR-133a, which regulates their mRNAs, can serve as a strong tumour suppressor of ESCC.
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Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma.
Yuka Isozaki,Isamu Hoshino,Nijiro Nohata,Takashi Kinoshita,Yasunori Akutsu,Naoyuki Hanari,Mikito Mori,Yasuo Yoneyama,Naoki Akanuma,Nobuyoshi Takeshita,Tetsuro Maruyama,Naohiko Seki,Norikazu Nishino,Minoru Yoshida,Hisahiro Matsubara +14 more
TL;DR: Results indicate that HDACIs upregulate miRNAs, at least some of which act as tumor suppressors, and LDHB, which is regulated by the tumor suppressive miR-375, may act as an oncogene in ESCC.
Journal ArticleDOI
miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1.
Nobuyoshi Takeshita,Mikito Mori,Masayuki Kano,Isamu Hoshino,Yasunori Akutsu,Naoyuki Hanari,Yasuo Yoneyama,Norimasa Ikeda,Yuka Isozaki,Tetsurou Maruyama,Naoki Akanuma,Yukimasa Miyazawa,Hisahiro Matsubara +12 more
TL;DR: The results suggest that miR-203 and its target LASP1, may be associated with the progression of ESCC, and could provide new insights into the potential cancer network regulated by the microRNA-203.