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Akihiko Okuyama

Researcher at Osaka University

Publications -  497
Citations -  11210

Akihiko Okuyama is an academic researcher from Osaka University. The author has contributed to research in topics: Transplantation & Kidney. The author has an hindex of 53, co-authored 481 publications receiving 10678 citations.

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Excellent long-term outcome of ABO-incompatible living donor kidney transplantation in Japan.

TL;DR: Long‐term outcome in recipients of ABO‐incompatible living kidneys is excellent, and graft survival rates were significantly higher in patients 29 years or younger than in patients 30 years or older and in patients who received anticoagulation therapy than in those who did not receive such therapy.
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Novel 5α‐steroid reductase (SRD5A3, type‐3) is overexpressed in hormone‐refractory prostate cancer

TL;DR: Findings indicate that a novel type 3 5α‐steroid reductase, SRD5A3, is associated with DHT production and maintenance of androgen–androgen receptor‐pathway activation in HRPC cells, and that this enzymatic activity should be a promising molecular target for prostate cancer therapy.
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Retrospective study on the impact of hepatitis C virus infection on kidney transplant patients over 20 years.

TL;DR: HCV infection has a significant impact on kidney transplant recipients over the long term and in particular affects them in the second decade, and a pilot study revealed only partial efficacy of IFN-alpha therapy for HCV-infected recipients, but with the high risk of acute rejection.
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Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer.

TL;DR: This is the first report about CYP1B1 regulation in human clinical prostate samples showing that hypomethylation of the CYP 1B1 gene may play an important role in prostate cancer.