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Akio Wanaka
Researcher at Nara Medical University
Publications - 171
Citations - 7431
Akio Wanaka is an academic researcher from Nara Medical University. The author has contributed to research in topics: Gene expression & Embryonic stem cell. The author has an hindex of 47, co-authored 164 publications receiving 7024 citations. Previous affiliations of Akio Wanaka include Washington University in St. Louis & Fukushima Medical University.
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Journal ArticleDOI
Lysophosphatidylcholine induces delayed myelination in the juvenile ventral hippocampus and behavioral alterations in adulthood.
Manabu Makinodan,Kouko Tatsumi,Hiroaki Okuda,Takayuki Manabe,Takahira Yamauchi,Yoshinobu Noriyama,Toshifumi Kishimoto,Akio Wanaka +7 more
TL;DR: The findings suggest that the timing of myelination in the early postnatal hippocampus is crucial for the proper development of sensorimotor and emotional functions and the lysophosphatidylcholine-treated rat without a gross anatomical defect is useful as a model for psychotic disorders.
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Chondroitin sulfate demarcates astrocytic territories in the mammalian cerebral cortex
Noriko Horii-Hayashi,Kouko Tatsumi,Yumiko Matsusue,Hiroaki Okuda,Aya Okuda,Motoharu Hayashi,Humiko Yano,Akio Tsuboi,Mayumi Nishi,Masahide Yoshikawa,Akio Wanaka +10 more
TL;DR: It is found that another anti-CS antibody (anti-CS-C) was also able to detect the DACS and the morphological analysis revealed that a single DACS enwrapped five to six neuronal somata on average, which indicated that DACS coincided with a single astrocyte territory.
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The Role of the Wnt Signaling Pathway in Upper Jaw Development of Chick Embryo.
Tadahiro Shimomura,Masayoshi Kawakami,Kouko Tatsumi,Tatsuhide Tanaka,Shoko Morita-Takemura,Tadaaki Kirita,Akio Wanaka +6 more
TL;DR: The data suggest that the Wnt signaling pathway regulates maxillary morphogenesis and growth through Bmp4, Tbx22, Sox9, and Barx1 and might regulate N-cadherin expression via Msx1, resulting in cell aggregation for osteochondrogenesis.
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Expression of c-fos mRNA after cortical ablation in rat brain is modulated by basic fibroblast growth factor (bFGF) and the NMDA receptor is involved in c-fos expression.
TL;DR: The results suggest that induction of c-fos after cortical injury can be modulated by topically applied bFGF and that the N-methyl-D-aspartate (NMDA) receptor is involved in c- fos expression not only caused by injury itself but also induced by injury and bF GF.
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Efficient induction of inner ear hair cell-like cells from mouse ES cells using combination of Math1 transfection and conditioned medium from ST2 stromal cells.
Yukiteru Ouji,Masaharu Sakagami,Hiroko Omori,Shinji Higashiyama,Norikazu Kawai,Tadashi Kitahara,Akio Wanaka,Masahide Yoshikawa +7 more
TL;DR: Analysis of expressions of marker genes specific for cochlear- and vestibular-type cells indicated that the HIST2 method may lead to induction of cochEar hair cell-like cells andvestibular cells, which showed remarkable formation of stereocilia-like structures.