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Akio Wanaka
Researcher at Nara Medical University
Publications - 171
Citations - 7431
Akio Wanaka is an academic researcher from Nara Medical University. The author has contributed to research in topics: Gene expression & Embryonic stem cell. The author has an hindex of 47, co-authored 164 publications receiving 7024 citations. Previous affiliations of Akio Wanaka include Washington University in St. Louis & Fukushima Medical University.
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Yi-gan san restores behavioral alterations and a decrease of brain glutathione level in a mouse model of schizophrenia.
Manabu Makinodan,Takahira Yamauchi,Kouko Tatsumi,Hiroaki Okuda,Yoshinobu Noriyama,Miyuki Sadamatsu,Toshifumi Kishimoto,Akio Wanaka +7 more
TL;DR: Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice, suggesting that yi-GAN san may have ameliorating effects on the pathological symptoms of schizophrenia.
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Knockdown of the L3/Lhx8 gene suppresses cholinergic differentiation of murine embryonic stem cell-derived spheres
Takayuki Manabe,Kouko Tatsumi,Masahide Inoue,Hiroko Matsuyoshi,Manabu Makinodan,Takahira Yamauchi,Eri Makinodan,Shohei Yokoyama,Ryoko Sakumura,Hiroaki Okuda,Akio Wanaka +10 more
TL;DR: The in vitro effects of reduced L3/Lhx8 gene expression on cholinergic differentiation in murine embryonic stem (ES) cell‐derived spheres without dissociation suggest that L2/Lx8 is a key factor for cholinergic differentiation of murine ES cell‐ derived spheres and is involved in basal forebrain development.
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NGF and BDNF expression in mouse DRG after spared nerve injury
Yuki Terada,Shoko Morita-Takemura,Ayami Isonishi,Tatsuhide Tanaka,Hiroshi Okuda,Kouko Tatsumi,Takeaki Shinjo,Masahiko Kawaguchi,Akio Wanaka +8 more
TL;DR: To elicit neuropathic pain, the spared nerve injury model is used, in which injured DRG neurons are distinguishable from intact ones, and mechanical allodynia develops in the intact sural nerve skin territory, and nerve growth factor and brain-derived neurotrophic factor expression in the DRGs of SNI model mice are examined.
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Large-scale electron microscopic volume imaging of interfascicular oligodendrocytes in the mouse corpus callosum
Tatsuhide Tanaka,Nobuhiko Ohno,Yasuyuki Osanai,Yasuyuki Osanai,Sei Saitoh,Truc Quynh Thai,Kazuya Nishimura,Takeaki Shinjo,Shoko Takemura,Kouko Tatsumi,Akio Wanaka +10 more
TL;DR: In this paper, the authors used serial block face scanning electron microscopy (SFCEM) to reconstruct the myelin sheaths from the corpus callosum of the adult mouse.