A
Akira Hashiramoto
Researcher at RMIT University
Publications - 64
Citations - 3878
Akira Hashiramoto is an academic researcher from RMIT University. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 24, co-authored 60 publications receiving 3674 citations. Previous affiliations of Akira Hashiramoto include National Institutes of Health & Kobe University.
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Journal Article
Expression of Cyclooxygenase-1 and -2 in Human Colorectal Cancer
Hajime Sano,Yutaka Kawahito,Ronald L. Wilder,Akira Hashiramoto,Shigehiko Mukai,Kiyoshi Asai,Shigeru Kimura,Haruki Kato,Motoharu Kondo,Timothy Hla +9 more
TL;DR: The data suggest that the enhanced expression of the COX-2 gene in Colon cancer tissues may contribute to the enhanced synthesis of prostaglandin E2 by the colon cancer tissues.
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Enhanced insulin sensitivity in mice lacking ganglioside GM3
Tadashi Yamashita,Akira Hashiramoto,Martin Haluzik,Hiroki Mizukami,Shoshannah L. Beck,Aaron T. Norton,Mari Kono,Shuichi Tsuji,Jose L. Daniotti,Norbert Werth,Roger Sandhoff,Konrad Sandhoff,Richard L. Proia +12 more
TL;DR: Results show that GM3 ganglioside is a negative regulator of insulin signaling, making it a potential therapeutic target in type 2 diabetes, and protected from high-fat diet-induced insulin resistance.
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15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats
Yutaka Kawahito,Motoharu Kondo,Yasunori Tsubouchi,Akira Hashiramoto,David Bishop-Bailey,Ken-ichiro Inoue,Masataka Kohno,Ryoji Yamada,Timothy Hla,Hajime Sano +9 more
TL;DR: It is demonstrated that synovial tissue localized expression of PPAR-γ in patients with rheumatoid arthritis (RA) and its ligands, especially 15d-PGJ2, may be useful in the treatment of RA, to suggest that PPar-γ may be an important immunoinflammatory mediator.
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Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1.
Yukihiko Aikawa,Kimiko Morimoto,Tetsuya Yamamoto,Hisaaki Chaki,Akira Hashiramoto,Hirokazu Narita,Shuichi Hirono,Shunichi Shiozawa +7 more
TL;DR: Selective inhibition of c-Fos/AP-1 resolves arthritis in a preclinical model of the disease.
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Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-α
Akira Hashiramoto,Takashi Yamane,Ken Tsumiyama,Kohsuke Yoshida,Koichiro Komai,Hiroyuki Yamada,Fumiyoshi Yamazaki,Masao Doi,Hitoshi Okamura,Shunichi Shiozawa +9 more
TL;DR: The biological clock and arthritis influence each other, and this interplay can influence human health and disease.