T
Timothy Hla
Researcher at Boston Children's Hospital
Publications - 305
Citations - 42012
Timothy Hla is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Receptor & Sphingosine. The author has an hindex of 104, co-authored 293 publications receiving 39139 citations. Previous affiliations of Timothy Hla include University of Connecticut & University of Connecticut Health Center.
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Journal ArticleDOI
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
TL;DR: Characterization of the two COX isozymes is allowing the discrimination of the roles each play in physiological processes such as homeostatic maintenance of the gastrointestinal tract, renal function, blood clotting, embryonic implantation, parturition, pain, and fever.
Journal ArticleDOI
Human cyclooxygenase-2 cDNA.
Timothy Hla,Karen M. Neilson +1 more
TL;DR: High-level induction of the hCox-2 transcript in mesenchymal-derived inflammatory cells suggests a role in inflammatory conditions and demonstrates that the Cox enzyme is encoded by at least two genes that are expressed and differentially regulated in a variety of cell types.
Journal ArticleDOI
Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
Yujing Liu,Ryuichi Wada,Tadashi Yamashita,Yide Mi,Chu-Xia Deng,John P. Hobson,Hans M. Rosenfeldt,Victor E. Nava,Sung Suk Chae,Menq Jer Lee,Catherine H. Liu,Timothy Hla,Sarah Spiegel,Richard L. Proia +13 more
TL;DR: The data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development.
Journal Article
Expression of Cyclooxygenase-1 and -2 in Human Colorectal Cancer
Hajime Sano,Yutaka Kawahito,Ronald L. Wilder,Akira Hashiramoto,Shigehiko Mukai,Kiyoshi Asai,Shigeru Kimura,Haruki Kato,Motoharu Kondo,Timothy Hla +9 more
TL;DR: The data suggest that the enhanced expression of the COX-2 gene in Colon cancer tissues may contribute to the enhanced synthesis of prostaglandin E2 by the colon cancer tissues.
Journal ArticleDOI
Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1
Menq Jer Lee,James R. Van Brocklyn,James R. Van Brocklyn,James R. Van Brocklyn,Shobha Thangada,Shobha Thangada,Shobha Thangada,Catherine H. Liu,Catherine H. Liu,Catherine H. Liu,Arthur R. Hand,Arthur R. Hand,Arthur R. Hand,Ramil Menzeleev,Ramil Menzeleev,Ramil Menzeleev,Sarah Spiegel,Sarah Spiegel,Sarah Spiegel,Timothy Hla,Timothy Hla,Timothy Hla +21 more
TL;DR: Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho.