Alain Béchetoille

TL;DR: Surprisingly, the TIGR message, which is abundantly transcribed in the trabecular meshwork and also in the ciliary body and the sclera, is not expressed in the optic nerve whose degeneration is, however, the primary lesion of POAG.

TL;DR: It is reported that two APOE-promoter single-nucleotide polymorphisms (SNPs) previously associated with AD also modify the POAG phenotype, establish APOE as a potent modifier for POAG, and shed new light on potential mechanisms of optic nerve damage and of IOP regulation in POAG.

TL;DR: The influence on glaucoma phenotype of a novel biallelic polymorphism located in the upstream region of the MYOC gene appears to be an indicator of poor IOP control and greater visual field damage in diagnosed POAG patients, potentially due to a lack of response to therapeutic intervention.

TL;DR: A second POAG family with variable age of onset is described, strengthening the idea that early-onset POAG may also be determined by the GLC1A genetic region.

TL;DR: Testing linkage of familial OAG to GLC1A may have prognostic value too, as there was strong evidence of genetic heterogeneity in eight French families with multiple cases of juvenile and middle age onset OAG.