Alain Charest

TL;DR: It is established that proteins of 100–130 kDa are highly phosphorylated following stimulation of epithelial cells and that one of these is the Grb2-associated binding protein Gab1, a possible insulin receptor substrate-1-like signal transducer, and that Gab1 is the major substrate for the Met kinase in vitro and in vivo.

TL;DR: A multidisciplinary strategy is described for the characterization of the 5-HT1A receptor at the level of cellular signaling mechanisms and genetic regulation, which may suggest novel sties of inherent defect involved in anxiety syndromes or major depression.

TL;DR: Habib et al. as mentioned in this paper showed that the interaction between murine SHC and protein-tyrosine phosphatase-PEST is mediated through the PTB/PI domain of SHC, which is not dependent on the presence of a tyrosine-phosphorylated residue in the target sequence.

TL;DR: In this article, the authors have isolated the murine cDNA homologue of the human protein tyrosine phosphatase PTP-PEST from an 18.5-day mouse embryonic kidney library.

TL;DR: A novel SH3 domain-dependent recruitment of a protein tyrosine phosphatase to an activated receptor tyrosinesine kinase is described and a potential role for MPTP – PEST in signalling pathways at the molecular level is established.