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Alain Haziot
Researcher at North Shore University Hospital
Publications - 22
Citations - 2853
Alain Haziot is an academic researcher from North Shore University Hospital. The author has contributed to research in topics: CD14 & Lipopolysaccharide. The author has an hindex of 14, co-authored 20 publications receiving 2801 citations. Previous affiliations of Alain Haziot include Brooklyn Hospital Center & New York University.
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Journal ArticleDOI
Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice
Alain Haziot,Enza Ferrero,Frank Köntgen,Naoki Hijiya,Shunsuke Yamamoto,Jack Silver,Colin L. Stewart,Sanna M. Goyert +7 more
TL;DR: In this article, the role of CD14 in bacterial-induced and LPS-induced shock was tested in CD14-deficient mice produced by gene targeting in embryonic stem cells.
Journal Article
The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.
TL;DR: It is demonstrated that CD14 is a member of the family of PI-anchored proteins and suggest that soluble forms of CD14 represent molecules that completely lack thePI-anchoring system.
Journal ArticleDOI
Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.
TL;DR: The results document the importance of CD14 in vivo as a primary mediator of this lethal syndrome and provide an important model for testing the therapeutic effects of agents directed specifically against the human, as opposed to the murine, CD14 protein in preventing LPS-induced endotoxin shock.
Journal Article
Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide.
TL;DR: Results show that while the membrane form of CD14 can function as a receptor, its soluble form canfunction as a co-ligand with LPS in the EC-LPS response.
Journal Article
Neutrophil CD14: biochemical properties and role in the secretion of tumor necrosis factor-alpha in response to lipopolysaccharide.
TL;DR: The described properties and function of neutrophil CD14 suggest that it may directly participate in the acute inflammatory response and in endotoxin shock.