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Alain Haziot

Researcher at North Shore University Hospital

Publications -  22
Citations -  2853

Alain Haziot is an academic researcher from North Shore University Hospital. The author has contributed to research in topics: CD14 & Lipopolysaccharide. The author has an hindex of 14, co-authored 20 publications receiving 2801 citations. Previous affiliations of Alain Haziot include Brooklyn Hospital Center & New York University.

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Journal ArticleDOI

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

TL;DR: In this article, the role of CD14 in bacterial-induced and LPS-induced shock was tested in CD14-deficient mice produced by gene targeting in embryonic stem cells.
Journal Article

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

TL;DR: It is demonstrated that CD14 is a member of the family of PI-anchored proteins and suggest that soluble forms of CD14 represent molecules that completely lack thePI-anchoring system.
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Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.

TL;DR: The results document the importance of CD14 in vivo as a primary mediator of this lethal syndrome and provide an important model for testing the therapeutic effects of agents directed specifically against the human, as opposed to the murine, CD14 protein in preventing LPS-induced endotoxin shock.
Journal Article

Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide.

TL;DR: Results show that while the membrane form of CD14 can function as a receptor, its soluble form canfunction as a co-ligand with LPS in the EC-LPS response.
Journal Article

Neutrophil CD14: biochemical properties and role in the secretion of tumor necrosis factor-alpha in response to lipopolysaccharide.

TL;DR: The described properties and function of neutrophil CD14 suggest that it may directly participate in the acute inflammatory response and in endotoxin shock.