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Alain Hehn
Researcher at University of Lorraine
Publications - 85
Citations - 3528
Alain Hehn is an academic researcher from University of Lorraine. The author has contributed to research in topics: Furanocoumarin & Phenylpropanoid. The author has an hindex of 30, co-authored 81 publications receiving 3077 citations. Previous affiliations of Alain Hehn include Centre national de la recherche scientifique & Institut national de la recherche agronomique.
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Journal ArticleDOI
CYP98A3 from Arabidopsis thaliana Is a 3′-Hydroxylase of Phenolic Esters, a Missing Link in the Phenylpropanoid Pathway
Guillaume A. Schoch,Simon Goepfert,Marc Morant,Alain Hehn,Denise Meyer,Pascaline Ullmann,Danièle Werck-Reichhart +6 more
TL;DR: It is shown that the gene encoding CYP98A3, which was the best possible P450 candidate for a 3-hydroxylase in the Arabidopsis genome, is highly expressed in inflorescence stems and wounded tissues and catalyzes the synthesis of chlorogenic acid and very likely also the 3-Hydroxylation of lignin monomers.
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Cytochromes P450 for engineering herbicide tolerance
TL;DR: The recovery of an increasing number of plant P450 genes in recombinant form has enabled their use in experimentation, which has revealed their extraordinary potential for engineering herbicide tolerance, biosafening, bioremediation and green chemistry.
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Biosynthesis of coumarins in plants: a major pathway still to be unravelled for cytochrome P450 enzymes
Frédéric Bourgaud,Alain Hehn,Romain Larbat,S. Doerper,Eric Gontier,Sandra Kellner,Ulrich Matern +6 more
TL;DR: This review highlights the major steps of the coumarin pathway with emphasis on the cytochrome P450 enzymes involved, including Ortho-hydroxylation of hydroxycinnamic acids, and the outcomes of novel strategies developed to uncover cou marin-committed CYPs.
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Crosstalk and differential response to abiotic and biotic stressors reflected at the transcriptional level of effector genes from secondary metabolism.
Sabine Glombitza,Pierre-Henri Dubuis,Oliver Thulke,Gerhard Welzl,Lucien Bovet,Lucien Bovet,Michael Götz,Matthias Affenzeller,Birgit Geist,Alain Hehn,Carole Asnaghi,Dieter Ernst,Harald K Seidlitz,Heidrun Gundlach,Klaus F. X. Mayer,Enrico Martinoia,Danièle Werck-Reichhart,Felix Mauch,Anton R. Schäffner +18 more
TL;DR: Interestingly, a subset of genes induced by P. syringae was not responsive to the applied stress hormones, and homologous members within branches of these effector gene families displayed differential expression patterns either in both organs or during stress responses arguing for their non-redundant functions.
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Evolution of a novel phenolic pathway for pollen development.
Michiyo Matsuno,Vincent Compagnon,Guillaume A. Schoch,Martine Schmitt,Delphine Debayle,Jean-Etienne Bassard,Brigitte Pollet,Alain Hehn,Dimitri Heintz,Pascaline Ullmann,Catherine Lapierre,François Bernier,Jürgen Ehlting,Danièle Werck-Reichhart +13 more
TL;DR: A retroposition, neofunctionalization, and duplication sequence that, via selective and local amino acid replacement, led to the evolution of a novel phenolic pathway in Brassicaceae is described and shows how positive Darwinian selection can favor structured clusters of nonsynonymous substitutions that are needed for the transition of enzymes to new functions.