A
Alakananda Basu
Researcher at University of Pittsburgh
Publications - 30
Citations - 1577
Alakananda Basu is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Protein kinase C & Glucocerebrosidase. The author has an hindex of 18, co-authored 30 publications receiving 1561 citations. Previous affiliations of Alakananda Basu include Mayo Clinic.
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Overexpression of metallothionein confers resistance to anticancer drugs.
TL;DR: Tumor cell lines with acquired resistance to the antineoplastic agent cis-diamminedichloroplatinum(II) overexpressed metallothionein and demonstrated cross-resistance to alkylating agents such as chlorambucil and melphalan.
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The potential of protein kinase C as a target for anticancer treatment
TL;DR: A complete understanding of the PKC signal transduction pathway is obligatory for the selective destruction of tumor tissue by exploiting PKC as either a target or a modulator of cancer chemotherapeutic agents.
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Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to cis-diamminedichloroplatinum(II).
TL;DR: Activation of protein kinase C by TPA appears to be necessary but not sufficient for cellular sensitization to CP, as the increase in platinum content caused by a 24-h pretreatment with PDBu was associated with a concentration- and time-dependent increase in cellular platinum content.
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A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs
Alakananda Basu,John S. Lazo +1 more
TL;DR: The proposition that intracellular metallothioneins may have a role in determining the toxicity of anticancer agents to non-malignant tissues is discussed.
Journal Article