Alan J. Riordan

TL;DR: A time-intensity profile similarity (TIPS) bilateral filter is proposed to reduce noise in 4D CTP scans, while preserving the time- intensity profiles (fourth dimension) that are essential for determining the perfusion parameters.

TL;DR: A dynamic hybrid head phantom constructed from CT and MRI data was demonstrated to realistically represent clinical CTP studies, which is useful for assessing CT brain perfusion acquisition, reconstruction, and analysis.

TL;DR: The presented registration technique can be used to automatically quantify the movement during acquisition, which can assist identification of CTP datasets with excessive head movement.

TL;DR: With the use of IR in CTP imaging it is possible to examine patients with a half dose without significantly altering the objective and diagnostic IQ, and the standard dose is still preferable in terms of subjective overall IQ in about one quarter of patients.

TL;DR: CT Perfusion acquisition times <60 seconds are too short to capture the complete in and out-wash of contrast in the tissue, resulting in incomplete time attenuation curves, and truncation is common in patients with large vessel occlusion and results in repartitioning of the area of hypoperfusion into larger ischemic core and smaller penumbra estimations.