A
Alan McBurney
Researcher at University of Leicester
Publications - 10
Citations - 246
Alan McBurney is an academic researcher from University of Leicester. The author has contributed to research in topics: Pinacidil & Cmax. The author has an hindex of 6, co-authored 10 publications receiving 244 citations. Previous affiliations of Alan McBurney include Clatterbridge Cancer Centre NHS Foundation Trust.
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Journal ArticleDOI
Oxidative damage to DNA in patients with cystic fibrosis
TL;DR: It is confirmed that patients with CF are susceptible to oxidative-induced DNA damage, although this appears to be independent of clinical status.
Journal ArticleDOI
Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin.
John C McGourty,John C McGourty,Joseph H Silas,Joseph H Silas,Jude J Fleming,Jude J Fleming,Alan McBurney,Alan McBurney,J. W. Ward,J. W. Ward +9 more
TL;DR: In this article, pharmacokinetics and beta-blocking effects of a single, oral 20 mg dose of timolol in six poor metabolizers and six extensive metabolizers (EMs) of debrisoquin were studied.
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Pharmacokinetics and hypotensive effect in healthy volunteers of pinacidil, a new potent vasodilator.
TL;DR: It was concluded that intravenous pinacidil is a potent vasodilator hypotensive compound, with a duration of action between 1.5 and 2 h.
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Hemodialysis and iopamidol clearance after subclavian venography.
TL;DR: Hemodialysis is a rapid and efficient means of clearing iopamidol provided it is performed soon after the contrast study, and for anuric patients, extrarenal clearance provided total body clearance of up to 0.266 L/hr.
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Serum concentrations and urinary excretion of pinacidil and its major metabolite, pinacidil pyridine‐N‐oxide following i.v. and oral administration in healthy volunteers.
TL;DR: Pinacidil pyridine-N-oxide may be a 'first-pass' metabolite of pinacidil, which is unlikely to contribute significantly to the hypotensive effect of Pinacidil in most patients.