Journal ArticleDOI
Oxidative damage to DNA in patients with cystic fibrosis
TLDR
It is confirmed that patients with CF are susceptible to oxidative-induced DNA damage, although this appears to be independent of clinical status.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1995-04-01. It has received 102 citations till now. The article focuses on the topics: FEV1/FVC ratio.read more
Citations
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The importance of glutathione in human disease.
TL;DR: An overview of the biological importance of GSH at the level of the cell and organism can be found in this article, where the authors provide a review of the most prevalent non-protein thiol in animal cells.
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Reactive oxygen species: role in the development of cancer and various chronic conditions
Gulam Waris,Haseeb Ahsan +1 more
TL;DR: Elevated levels of ROS and down regulation of ROS scavengers and antioxidant enzymes are associated with various human diseases including various cancers, also implicated in diabtes and neurodegenerative diseases.
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Oxidative DNA damage and disease: induction, repair and significance
TL;DR: The weight of evidence strongly suggests a link between such damage and the pathogenesis of disease, and the role of 8-OH-dG in disease, although exact roles remain to be elucidated.
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Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
TL;DR: The increase of the 8-OH-dG level in the cellular DNA, detected by HPLC-ECD method, was supported by its immunochemical detection and its enhanced repair activity, and the validity of the general use of 8-Hydroxy-2'-deoxyguanosine as a marker of cellular oxidative stress is discussed.
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Cancer risk and oxidative DNA damage in man
Steffen Loft,Henrik E. Poulsen +1 more
TL;DR: Human studies support the experimentally based notion of oxidative DNA damage as an important mutagenic and apparently carcinogenic factor in carcinogenesis, but the proof of a causal relationship in humans is still lacking.
References
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Journal ArticleDOI
Oxidative stress: oxidants and antioxidants
TL;DR: These low molecular mass antioxidant molecules add significantly to the defense provided by the enzymes superoxide dismutase, catalase and glutathione peroxidases, which are termed ‘oxidative stress’.
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Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair
Hiroshi Kasai,Pamela F. Crain,Yoshiyuki Kuchino,Susumu Nishimura,Akira Ootsuyama,Hiroshi Tanooka +5 more
TL;DR: The results indicate that 8-OH-dG is formed in vivo in cellular DNA on treatment with various oxygen radical-producing agents and that it is repairable and that its content is increase in Salmonella typhimurium cells with hydrogen peroxide.
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The respiratory burst of phagocytes.
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Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
TL;DR: Analysis of urine from three species by this method indicates that mice excrete approximately 3.3-fold more 8-hydroxy-2'-deoxyguanosine than humans, a result that supports the proposal that oxidative damage to DNA increases in proportion to species-specific basal metabolic rates.
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Endogenous Oxidative DNA Damage, Aging, and Cancer
TL;DR: The endogenous background level of oxidant-induced DNA damage in vivo has been assayed and the level of oxidative DNA damage as measured by oh8dG in normal rat liver is shown to be extensive, especially in mtDNA.