Showing papers by "Alan R. Giles published in 2000"

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Journal Article•DOI•

Proteolytic processing of human coagulation factor IX by plasmin

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John A. Samis¹, Gillian D. Ramsey¹, John Walker¹, Michael E. Nesheim¹, Alan R. Giles¹ - Show less +1 more•Institutions (1)

Queen's University¹

01 Feb 2000-Blood

TL;DR: The results suggest that plasmin is able to down-regulate coagulation by inactivating F.IX and decreased F.ix clotting activity.

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45 citations

Journal Article•DOI•

Aortic endothelial cell von Willebrand factor content, and circulating plasminogen activator inhibitor-1 are increased, but expression of endothelial leukocyte adhesion molecules is unchanged in insulin-dependent diabetic BB rats.

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José C.O Ribau¹, John A. Samis², Yotis A. Senis², Donald H. Maurice², Alan R. Giles², Marnie DeReske¹, P. Marlene Absher³, Mark W.C. Hatton¹, Mary Richardson¹ - Show less +5 more•Institutions (3)

McMaster University¹, Queen's University², University of Vermont³

01 Apr 2000-Atherosclerosis

TL;DR: Endothelial alterations in BB rats associated with diabetes, together with the raised plasma PAI-1 levels, promote the thrombogenic potential of the vessel wall, and are consistent with an increased risk for vascular disease.

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5 citations