Alane M. Gray

TL;DR: The data indicate that the discrepancy between EGF levels in male and female mouse submaxillary glands (MSGs) is due to different EGF mRNA levels in these tissues, and suggest that precursor EGF processing may differ from that described previously for other polypeptide hormones.

TL;DR: The isolation of mouse β-NGF complementary DNA (cDNA) is described and its nucleotide sequence is presented, which predicts a prepro-β- NGF molecule of Mr 27,000 (27K) and a pro-β -NGF molecules of Mr 25K.

TL;DR: Re recombinant plasmids containing the entire Escherichia coli rrnB ribosomal RNA operon and segments thereof become a powerful tool for studies such as initiation and termination of transcription, processing of rRNA precursors, and investigations of the structure, function, and assembly of the ribosome itself.

TL;DR: This work has identified cDNA clones from a human glioma cell line that encode a secreted protein with 32% amino acid identity to VEGF that specifically binds to the extracellular domain of Flt4, stimulates the tyrosine phosphorylation of FlT4 expressed in mammalian cells, and promotes the mitogenesis of human lung endothelial cells.

TL;DR: This study uncovers a dynamic process during which gradual separation and proper spatial arrangement of the angioblasts allow subsequent assembly of vascular tubes, leading to the failure of vascular tube formation in Egfl7 knockdown embryos.