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William I. Wood
Researcher at Genentech
Publications - 354
Citations - 25428
William I. Wood is an academic researcher from Genentech. The author has contributed to research in topics: Nucleic acid & Receptor. The author has an hindex of 62, co-authored 354 publications receiving 25020 citations. Previous affiliations of William I. Wood include University of California, Santa Cruz & University of California.
Papers
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Journal ArticleDOI
Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors
James P. Sheridan,Scot A. Marsters,Robert M. Pitti,Austin L. Gurney,Maya Skubatch,Daryl T. Baldwin,Lakshmi Ramakrishnan,Christa L. Gray,Kevin P. Baker,William I. Wood,Audrey Goddard,Paul J. Godowski,Avi Ashkenazi +12 more
TL;DR: A cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli in tumor cells.
Journal ArticleDOI
Growth hormone receptor and serum binding protein: purification, cloning and expression
David W. Leung,Steven A. Spencer,George Cachianes,R. Glenn Hammonds,Carol Collins,William J. Henzel,Ross Barnard,Michael J. Waters,William I. Wood +8 more
TL;DR: The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.
Journal ArticleDOI
A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression
Larry J. Suva,G. A. Winslow,Richard E.H. Wettenhall,R Hammonds,Jane M. Moseley,H. Diefenbach-Jagger,Christine Rodda,Bruce E. Kemp,H. Rodriguez,E. Y. Chen,P. J. Hudson,T. J. Martin,William I. Wood +12 more
TL;DR: The isolation of full-length complementary DNA clones of a putative hypercalcemia factor, and the expression from the cloned DNA of the active protein in mammalian cells that has significant homology with parathyroid hormone in the amino-terminal region are reported.
Patent
Secreted and Transmembrane Polypeptides and Nucleic Acids Encoding the Same
Kevin P. Baker,Maureen Beresini,Laura DeForge,Luc Desnoyers,Ellen Filvaroff,Wei-Qiang Gao,Mary E. Gerritsen,Audrey Goddard,Paul J. Godowski,Austin L. Gurney,Steven Sherwood,Victoria Smith,Timothy A. Stewart,Daniel Tumas,Colin K. Watanabe,William I. Wood,Zemin Zhang +16 more
TL;DR: In this paper, the present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polyptides, and vectors and host cells comprising those nucleic amino acid sequences.
Journal ArticleDOI
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
Ruey-Bing Yang,Melanie R. Mark,Alane M. Gray,Arthur J Huang,Ming Hong Xie,Min Zhang,Audrey Goddard,William I. Wood,Austin L. Gurney,Paul J. Godowski +9 more
TL;DR: It is shown that Toll-like receptor 2 (TLR2) is a signalling receptor that is activated by LPS in a response that depends on LPS-binding protein and is enhanced by CD14, and that TLR2 is a direct mediator of signalling by L PS.