Showing papers by "Alasdair M. Barr published in 2000"
TL;DR: The results suggest that the effects of melatonin treatment on forced-swim test behaviours are sex- and test-dependent, and it is unlikely that melatonin's mechanism of action is a general inhibitory effect on motor activity.
126 citations
TL;DR: Results suggest that chronic, high levels of corticosterone are unlikely to cause anhedonia in rodents, and that subjects exhibited an unexpected but significantly increased sensitivity to the rewarding effects of brain stimulation.
39 citations
01 Jan 2000
TL;DR: It is suggested that chronic, high levels of corticosterone are unlikely to cause anhedonia in rodents and that subjects exhibited an unexpected but significantly increased sensitivity to the rewarding effects of brain stimulation after chronic treatment.
Abstract: Excessive levels of glucocorticoids have been implicated in the etiology of affective disorders in humans, and in a range of behavioral deficits in animals. In the present study, we used an established regimen of corticosterone administration (40 mg / kg, for 21 days) to determine its effects upon responding for rewarding brain stimulation in rats. After chronic treatment, subjects exhibited an unexpected but significantly increased sensitivity to the rewarding effects of brain stimulation. These results suggest that chronic, high levels of corticosterone are unlikely to cause anhedonia in rodents. © 2000 Elsevier Science B.V. All rights reserved. Theme: Neural basis of behavior
1 citations