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Alastair Kent
Researcher at Genetic Alliance
Publications - 22
Citations - 19974
Alastair Kent is an academic researcher from Genetic Alliance. The author has contributed to research in topics: Health care & Decision analysis. The author has an hindex of 9, co-authored 21 publications receiving 16788 citations. Previous affiliations of Alastair Kent include Genetic Alliance UK.
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Multi-Criteria Decision Analysis to Value Orphan Medicines
TL;DR: In this article, the authors identify the attributes to include in a value framework for orphan medicinal products (OMPs), determine their relative importance using a multi-criteria decision analysis (MCDA) process, and test whether an MCDA approach can support decision making in practice.
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Time for Change? The Why, What and How of Promoting Innovation to Tackle Rare Diseases - Is It Time to Update the EU's Orphan Regulation? And if so, What Should be Changed?
Denis Horgan,Barbara Moss,Stefania Boccia,Maurizio Genuardi,Maciej Gajewski,Gabriele Capurso,Pierre Fenaux,Béatrice Gulbis,Mariangela Pellegrini,María del Mar Mañú Pereira,Victoria Gutiérrez Valle,Iñaki Gutiérrez Ibarluzea,Alastair Kent,Ivana Cattaneo,Beata Jagielska,Ivica Belina,Birute Tumiene,Adrian Ward,Marisa Papaluca +18 more
TL;DR: The successes and limitation of both the regulation and its implementation mechanisms in the current regulatory context are explored, and some improvements that could maximise its benefits and boost rare disease research even further are suggested.
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Bringing Onco-innovation to Europe's Healthcare Systems: The Potential of Biomarker Testing, Real World Evidence, Tumour Agnostic Therapies to Empower Personalised Medicine
Denis Horgan,Gennaro Ciliberto,Pierfranco Conte,Giuseppe Curigliano,Luis Seijo,Luis M. Montuenga,Marina Chiara Garassino,Frédérique Penault-Llorca,Fabrizia Galli,Isabelle Ray-Coquard,Denis Querleu,Peter Riegman,Keith M. Kerr,Hendrik Van Poppel,Anders Bjartell,Giovanni Codacci-Pisanelli,Benedikt Westphalen,Jasmina Koeva-Balabanova,Angelo Paradiso,Z. Maravic,Vassiliki Fotaki,Núria Malats,Chiara Bernini,Simonetta Buglioni,Alastair Kent,Elisabetta Munzone,Ivica Belina,Jan P. van Meerbeeck,Michael J. Duffy,Beata Jagielska,Ettore Capoluongo +30 more
TL;DR: The main issues and proposals that emerged during the previous advisory boards organised by the European Alliance for Personalized Medicine which mainly focus on possible scenarios of harmonisation of both oncogenetic testing and management of cancer patients are shown.
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Safety of medicines and the use of animals in research
Frances R. Balkwill,Stephen Whitehead,Phil Willis,Nigel Gaymond,Alastair Kent,Clive P. Page,Robin Lovell-Badge,Roger J. Morris,Roger N. Lemon,Duncan Banks +9 more
TL;DR: In this study, participants had two or more obesity-associated comorbid ities and treatment with phentermine plus topiramate led to improvements in lipids, glycaemic control, systolic blood pressure, and infl ammatory markers, pointing to a positive benefi t:risk ratio.
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Toward a proportionate regulatory framework for gene transfer: a patient group-led initiative.
TL;DR: A “Platform for Progress” is proposed that will help to facilitate the translation of gene transfer research and GCTMP development into the clinic as safely, and as efficiently as possible.