R
Roger J. Morris
Researcher at King's College London
Publications - 69
Citations - 5169
Roger J. Morris is an academic researcher from King's College London. The author has contributed to research in topics: Antigen & Receptor. The author has an hindex of 39, co-authored 69 publications receiving 5040 citations. Previous affiliations of Roger J. Morris include University of Oxford & Wolfson Centre for Age-Related Diseases.
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Journal ArticleDOI
Mutant mice and neuroscience: Recommendations concerning genetic background
Alcino J. Silva,Elizabeth M. Simpson,Joseph S. Takahashi,Hans-Peter Lipp,Shigetada Nakanishi,Jeanne M. Wehner,Karl Peter Giese,Tim Tully,Ted Abel,Paul F. Chapman,Kevin Fox,Seth G. N. Grant,Shigeyoshi Itohara,Richard Lathe,Mark Mayford,James O. McNamara,Roger J. Morris,Marina R. Picciotto,John C. Roder,Hee-Sup Shin,Paul A. Slesinger,Daniel R. Storm,Michael P. Stryker,Susumu Tonegawa,Yanyan Wang,David P. Wolfer +25 more
TL;DR: The following scientists made significant contributions to the recommendations in the report on climate change made by the United Nations Educational, Scientific and Cultural Organization (UNESCO) in 2016.
Journal ArticleDOI
Functionally different GPI proteins are organized in different domains on the neuronal surface.
Nathalie Madore,Karen L. Smith,Catriona H. Graham,Angela Jen,Ken Brady,Susan M. Hall,Roger J. Morris +6 more
TL;DR: A structural diversity of the domains occupied by functionally different GPI proteins is demonstrated: Thy‐1, a negative regulator of transmembrane signalling; and prion protein, whose rapid endocytosis and Cu2+ binding suggest that it functions in metal ion uptake.
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The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein
Claire Sunyach,Angela Jen,Juelin Deng,Kathleen T. Fitzgerald,Yveline Frobert,Jacques Grassi,Mary W. McCaffrey,Roger J. Morris +7 more
TL;DR: It is demonstrated, in primary cultured neurons and the N2a neural cell line, that prion protein is rapidly and constitutively endocytosed, an activity dependent upon its initial basic residues (NH2‐KKRPKP).
Journal ArticleDOI
Transmembrane asymmetry and lateral domains in biological membranes.
TL;DR: Biological rafts are in general of nm scale, and almost certainly differ in size and stability in inner and outer monolayers, and any coupling between rafts in the two leaflets is probably transient and dependent not upon the properties of lipids, but on transmembrane proteins within the rafts.
Journal ArticleDOI
Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1
M. Nosten-Bertrand,M.L. Errington,Kerry P.S.J. Murphy,Y Tokugawa,E Barboni,E Barboni,Elena N. Kozlova,D Michalovich,R. G. Morris,Jack Silver,Colin L. Stewart,Timothy V. P. Bliss,Roger J. Morris,Roger J. Morris +13 more
TL;DR: In mice in which the gene encoding Thy-1 has been inactivated, there is a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus.