A
Alecia Cutler
Researcher at Cleveland Clinic
Publications - 15
Citations - 363
Alecia Cutler is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Diabetic retinopathy & Neovascularization. The author has an hindex of 8, co-authored 15 publications receiving 305 citations. Previous affiliations of Alecia Cutler include Cleveland Clinic Lerner College of Medicine.
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Journal ArticleDOI
Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo.
Quteba Ebrahem,Shyam S. Chaurasia,Amit Vasanji,Jian Hua Qi,Phillip A. Klenotic,Alecia Cutler,Kewal Asosingh,Serpil C. Erzurum,Bela Anand-Apte +8 more
TL;DR: The results suggest that MMPs act both upstream and downstream of V EGF and imply that potential combination therapies of VEGF and MMP inhibitors may be a useful therapeutic approach in diseases of pathological neovascularization.
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Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy.
Kevin Tan,Emma M. Lessieur,Alecia Cutler,Patrice Nerone,Amit Vasanji,Kewal Asosingh,Serpil C. Erzurum,Bela Anand-Apte +7 more
TL;DR: The results from these pilot studies suggest that ECFCs from patients with PDR are mobilized into the circulation but may be unable to migrate and repair damaged capillary endothelium, suggesting that EC FCs may be a potential therapeutic target in the prevention and treatment of diabetic vascular complications.
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Inhibition of EGF Signaling Protects the Diabetic Retina from Insulin-Induced Vascular Leakage
Masahiko Sugimoto,Alecia Cutler,Bailey Shen,Scot E. Moss,Sudha K. Iyengar,Sudha K. Iyengar,Ronald Klein,Judah Folkman,Bela Anand-Apte +8 more
TL;DR: In this study with diabetic mice, insulin treatment resulted in increased vascular leakage apparently mediated by betacellulin and signaling via the epidermal growth factor (EGF) receptor, and treatment with EGF receptor inhibitors reduced retinal vascular leakage in diabetic mice on insulin.
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Increased Neovascularization in Mice Lacking Tissue Inhibitor of Metalloproteinases-3
Quteba Ebrahem,Jian Hua Qi,Masahiko Sugimoto,Mariya Ali,Jonathan E. Sears,Alecia Cutler,Rama Khokha,Amit Vasanji,Bela Anand-Apte,Bela Anand-Apte +9 more
TL;DR: The results of these studies determine an accentuation of pathologic VEGF-mediated angiogenesis in the cornea and laser-induced CNV in mice lacking TIMP-3, implying that TIMp-3 may regulate the development of the choroidal vasculature and is a likely contributor to increased susceptibility to choroid neovascularization.
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Tissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice
Jian Hua Qi,Quteba Ebrahem,Mariya Ali,Alecia Cutler,Brent A. Bell,Nicholas Prayson,Jonathan E. Sears,Vera Knäuper,Gillian Murphy,Bela Anand-Apte +9 more
TL;DR: Tissue inhibitor of metalloproteinases-3 peptides are identified to be efficient inhibitors of angiogenesis and have a potential to be used therapeutically in diseases with increased neovascularization.