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Aleksander Sieroń
Researcher at Medical University of Silesia
Publications - 302
Citations - 5075
Aleksander Sieroń is an academic researcher from Medical University of Silesia. The author has contributed to research in topics: Photodynamic therapy & Glutathione reductase. The author has an hindex of 33, co-authored 292 publications receiving 4462 citations. Previous affiliations of Aleksander Sieroń include University of California, Los Angeles & Thomas Jefferson University.
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Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.
Alain Colige,Aleksander Sieroń,Shi-Wu Li,Ulrike Schwarze,Elizabeth M. Petty,Wladimir Wertelecki,William R. Wilcox,Deborah Krakow,Daniel H. Cohn,W. Reardon,Peter H. Byers,Charles M. Lapière,Darwin J. Prockop,Betty Nusgens +13 more
TL;DR: The mutations that cause Ehlers-Danlos syndrome type VIIC are identified in the six known affected human individuals and also in one strain of dermatosparactic calf and used bovine cDNA to isolate human pNPI.
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The c-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1
TL;DR: It is demonstrated that procollagen C-proteinase is identical to BMP-1, a member of the "astacin families" of zinc-requiring endopeptidases that play critical roles in embryonic hatching, dorsal/ventral patterning, and early developmental decisions.
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Procollagen N-proteinase and procollagen C-proteinase: Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling
TL;DR: The data suggest that both the N- and C-proteinases have important biological functions in addition to the roles in the processing of procollagens.
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cDNA cloning and expression of bovine procollagen I N-proteinase: A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components
TL;DR: The enzyme may play a role in development that is independent of its role in collagen biosynthesis, supported by the observation that in some tissues the levels of mRNA for the enzyme are disproportionately high relative to the apparent rate of collagen biosynthetic.
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Effective Photoimmunotherapy of Murine Colon Carcinoma Induced by the Combination of Photodynamic Therapy and Dendritic Cells
Ahmad Jalili,Marcin Makowski,Tomasz Switaj,Dominika Nowis,Grzegorz M. Wilczynski,Ewa Wilczek,Magdalena Chorazy-Massalska,A Radzikowska,Wlodzimierz Maslinski,Lukasz P. Bialy,Jacek Sienko,Aleksander Sieroń,Mariusz Adamek,Grzegorz W. Basak,Pawel Mroz,Ireneusz W. Krasnodębski,Marek Jakóbisiak,Jakub Golab +17 more
TL;DR: The feasibility and antitumor effectiveness demonstrated in these studies suggest that treatment protocols involving the administration of immature DCs in combination with PDT may have clinical potential.